Fluvirucin B6, a new macrolactam isolated from a marine-derived actinomycete of the genus Nocardiopsis

A new 14-membered macrolactam natural product, fluvirucin B6 ( 1 ), was isolated from a marine-derived actinomycete, Nocardiopsis sp. CNQ-115, via HPLC-UV guided isolation. The chemical structure of 1 was elucidated by 1D and 2D NMR spectroscopic data analysis. Compound 1 showed a weak activity agai...

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Veröffentlicht in:	Journal of antibiotics 2018-06, Vol.71 (6), p.609-612
Hauptverfasser:	Leutou, Alain S., Yang, Inho, Le, Tu Cam, Hahn, Dongyup, Lim, Kyung-Min, Nam, Sang-Jip, Fenical, William
Format:	Artikel
Sprache:	eng
Schlagworte:	631/326/41/2535 631/92/349 Actinomycetales - chemistry Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Bacteria Bacteriology Biomedical and Life Sciences Bioorganic Chemistry Brief Communication Chromatography, High Pressure Liquid Gram-Negative Bacteria - drug effects Gram-positive bacteria Gram-Positive Bacteria - drug effects Lactams - chemistry Lactams, Macrocyclic - chemistry Lactams, Macrocyclic - isolation & purification Lactams, Macrocyclic - pharmacology Life Sciences Liquid chromatography Magnetic Resonance Spectroscopy Medicinal Chemistry Microbial Sensitivity Tests Microbiology Molecular Structure Organic Chemistry Spectrophotometry, Ultraviolet
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Beschreibung
Zusammenfassung:	A new 14-membered macrolactam natural product, fluvirucin B6 ( 1 ), was isolated from a marine-derived actinomycete, Nocardiopsis sp. CNQ-115, via HPLC-UV guided isolation. The chemical structure of 1 was elucidated by 1D and 2D NMR spectroscopic data analysis. Compound 1 showed a weak activity against Gram-positive bacteria, whereas it was inactive against Gram-negative bacteria.
ISSN:	0021-8820 1881-1469
DOI:	10.1038/s41429-018-0033-3