Systemic treatment in adult uterine sarcomas
Uterine sarcomas (US) are rare mesenchymal tumours of the uterus and are divided mainly into uterine leiomyosarcoma (uLMS), low grade endometrial stromal sarcoma (LG-ESS), high grade endometrial stromal sarcoma (HG-ESS), adenosarcomas and high grade undifferentiated sarcoma (HGUS). US are often high...
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| Veröffentlicht in: | Critical reviews in oncology/hematology 2018-02, Vol.122, p.10-20 |
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| container_title | Critical reviews in oncology/hematology |
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| creator | Desar, I.M.E. Ottevanger, P.B. Benson, C. van der Graaf, W.T.A. |
| description | Uterine sarcomas (US) are rare mesenchymal tumours of the uterus and are divided mainly into uterine leiomyosarcoma (uLMS), low grade endometrial stromal sarcoma (LG-ESS), high grade endometrial stromal sarcoma (HG-ESS), adenosarcomas and high grade undifferentiated sarcoma (HGUS). US are often high-grade tumours with a high local recurrence rate and metastatic risk. We here discuss the current standard of care and knowledge of systemic therapy for adult uterine sarcomas, in particular uLMS, LG-ESS, HG-ESS and HGUS, in both the adjuvant as well as the metastatic setting. |
| doi_str_mv | 10.1016/j.critrevonc.2017.12.009 |
| format | Article |
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US are often high-grade tumours with a high local recurrence rate and metastatic risk. We here discuss the current standard of care and knowledge of systemic therapy for adult uterine sarcomas, in particular uLMS, LG-ESS, HG-ESS and HGUS, in both the adjuvant as well as the metastatic setting.</description><identifier>ISSN: 1040-8428</identifier><identifier>EISSN: 1879-0461</identifier><identifier>DOI: 10.1016/j.critrevonc.2017.12.009</identifier><identifier>PMID: 29458779</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Chemotherapy ; Chemotherapy, Adjuvant ; Endometrial Neoplasms - pathology ; Female ; Hormone therapy ; Humans ; Leiomyosarcoma - pathology ; Leiomyosarcoma - therapy ; Radiotherapy, Adjuvant ; Sarcoma - pathology ; Sarcoma - therapy ; Sarcoma, Endometrial Stromal - pathology ; Sarcoma, Endometrial Stromal - therapy ; Systemic treatment ; Targeted therapy ; Uterine Neoplasms - pathology ; Uterine Neoplasms - therapy ; Uterine sarcoma</subject><ispartof>Critical reviews in oncology/hematology, 2018-02, Vol.122, p.10-20</ispartof><rights>2017 The Authors</rights><rights>Copyright © 2017 The Authors. 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US are often high-grade tumours with a high local recurrence rate and metastatic risk. We here discuss the current standard of care and knowledge of systemic therapy for adult uterine sarcomas, in particular uLMS, LG-ESS, HG-ESS and HGUS, in both the adjuvant as well as the metastatic setting.</description><subject>Adult</subject><subject>Chemotherapy</subject><subject>Chemotherapy, Adjuvant</subject><subject>Endometrial Neoplasms - pathology</subject><subject>Female</subject><subject>Hormone therapy</subject><subject>Humans</subject><subject>Leiomyosarcoma - pathology</subject><subject>Leiomyosarcoma - therapy</subject><subject>Radiotherapy, Adjuvant</subject><subject>Sarcoma - pathology</subject><subject>Sarcoma - therapy</subject><subject>Sarcoma, Endometrial Stromal - pathology</subject><subject>Sarcoma, Endometrial Stromal - therapy</subject><subject>Systemic treatment</subject><subject>Targeted therapy</subject><subject>Uterine Neoplasms - pathology</subject><subject>Uterine Neoplasms - therapy</subject><subject>Uterine sarcoma</subject><issn>1040-8428</issn><issn>1879-0461</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOwzAQRS0EoqXwCyhLFiSMHSdOllDxkiqxANaW44wlV3kU26nUv8dVCyzZzMzizr0zh5CEQkaBlnfrTDsbHG7HQWcMqMgoywDqEzKnlahT4CU9jTNwSCvOqhm58H4NAJyX4pzMWM2LSoh6Tm7fdz5gb3US7VTocQiJHRLVTl1IpoDODph45fTYK39JzozqPF4d-4J8Pj1-LF_S1dvz6_J-lWpeQ0i1MYzmhmlTlAUWrOGNyrHQqlBNw_NYjKhrxHhEw5URldFlw3gTr9bI0eQLcnPw3bjxa0IfZG-9xq5TA46TlwxAUCpEDlFaHaTajd47NHLjbK_cTlKQe1ZyLf9YyT0rSZmMrOLq9TFlanpsfxd_4ETBw0GA8detRSe9tjhobK1DHWQ72v9TvgE9sIE4</recordid><startdate>201802</startdate><enddate>201802</enddate><creator>Desar, I.M.E.</creator><creator>Ottevanger, P.B.</creator><creator>Benson, C.</creator><creator>van der Graaf, W.T.A.</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201802</creationdate><title>Systemic treatment in adult uterine sarcomas</title><author>Desar, I.M.E. ; Ottevanger, P.B. ; Benson, C. ; van der Graaf, W.T.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c490t-cff213f2cf565e52b4ba3e5ca5abb43abbf799ee945b4af78fc6b24b046ce4ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Chemotherapy</topic><topic>Chemotherapy, Adjuvant</topic><topic>Endometrial Neoplasms - pathology</topic><topic>Female</topic><topic>Hormone therapy</topic><topic>Humans</topic><topic>Leiomyosarcoma - pathology</topic><topic>Leiomyosarcoma - therapy</topic><topic>Radiotherapy, Adjuvant</topic><topic>Sarcoma - pathology</topic><topic>Sarcoma - therapy</topic><topic>Sarcoma, Endometrial Stromal - pathology</topic><topic>Sarcoma, Endometrial Stromal - therapy</topic><topic>Systemic treatment</topic><topic>Targeted therapy</topic><topic>Uterine Neoplasms - pathology</topic><topic>Uterine Neoplasms - therapy</topic><topic>Uterine sarcoma</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Desar, I.M.E.</creatorcontrib><creatorcontrib>Ottevanger, P.B.</creatorcontrib><creatorcontrib>Benson, C.</creatorcontrib><creatorcontrib>van der Graaf, W.T.A.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Critical reviews in oncology/hematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Desar, I.M.E.</au><au>Ottevanger, P.B.</au><au>Benson, C.</au><au>van der Graaf, W.T.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Systemic treatment in adult uterine sarcomas</atitle><jtitle>Critical reviews in oncology/hematology</jtitle><addtitle>Crit Rev Oncol Hematol</addtitle><date>2018-02</date><risdate>2018</risdate><volume>122</volume><spage>10</spage><epage>20</epage><pages>10-20</pages><issn>1040-8428</issn><eissn>1879-0461</eissn><abstract>Uterine sarcomas (US) are rare mesenchymal tumours of the uterus and are divided mainly into uterine leiomyosarcoma (uLMS), low grade endometrial stromal sarcoma (LG-ESS), high grade endometrial stromal sarcoma (HG-ESS), adenosarcomas and high grade undifferentiated sarcoma (HGUS). US are often high-grade tumours with a high local recurrence rate and metastatic risk. We here discuss the current standard of care and knowledge of systemic therapy for adult uterine sarcomas, in particular uLMS, LG-ESS, HG-ESS and HGUS, in both the adjuvant as well as the metastatic setting.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>29458779</pmid><doi>10.1016/j.critrevonc.2017.12.009</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Chemotherapy Chemotherapy, Adjuvant Endometrial Neoplasms - pathology Female Hormone therapy Humans Leiomyosarcoma - pathology Leiomyosarcoma - therapy Radiotherapy, Adjuvant Sarcoma - pathology Sarcoma - therapy Sarcoma, Endometrial Stromal - pathology Sarcoma, Endometrial Stromal - therapy Systemic treatment Targeted therapy Uterine Neoplasms - pathology Uterine Neoplasms - therapy Uterine sarcoma |
| title | Systemic treatment in adult uterine sarcomas |
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