Systemic treatment in adult uterine sarcomas

Uterine sarcomas (US) are rare mesenchymal tumours of the uterus and are divided mainly into uterine leiomyosarcoma (uLMS), low grade endometrial stromal sarcoma (LG-ESS), high grade endometrial stromal sarcoma (HG-ESS), adenosarcomas and high grade undifferentiated sarcoma (HGUS). US are often high...

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Veröffentlicht in:	Critical reviews in oncology/hematology 2018-02, Vol.122, p.10-20
Hauptverfasser:	Desar, I.M.E., Ottevanger, P.B., Benson, C., van der Graaf, W.T.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Chemotherapy Chemotherapy, Adjuvant Endometrial Neoplasms - pathology Female Hormone therapy Humans Leiomyosarcoma - pathology Leiomyosarcoma - therapy Radiotherapy, Adjuvant Sarcoma - pathology Sarcoma - therapy Sarcoma, Endometrial Stromal - pathology Sarcoma, Endometrial Stromal - therapy Systemic treatment Targeted therapy Uterine Neoplasms - pathology Uterine Neoplasms - therapy Uterine sarcoma
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Beschreibung
Zusammenfassung:	Uterine sarcomas (US) are rare mesenchymal tumours of the uterus and are divided mainly into uterine leiomyosarcoma (uLMS), low grade endometrial stromal sarcoma (LG-ESS), high grade endometrial stromal sarcoma (HG-ESS), adenosarcomas and high grade undifferentiated sarcoma (HGUS). US are often high-grade tumours with a high local recurrence rate and metastatic risk. We here discuss the current standard of care and knowledge of systemic therapy for adult uterine sarcomas, in particular uLMS, LG-ESS, HG-ESS and HGUS, in both the adjuvant as well as the metastatic setting.
ISSN:	1040-8428 1879-0461
DOI:	10.1016/j.critrevonc.2017.12.009