CRISPRs from scratch

CRISPRs from scratch

CRISPR immunity begins with the acquisition of sequences from invading nucleic acids through spacer integration into a CRISPR locus. Off-target integration of spacers into other parts of the genome is now implicated as a spontaneous source of new CRISPR loci.

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Bibliographische Detailangaben
Veröffentlicht in:Nature microbiology 2018-03, Vol.3 (3), p.261-262
Hauptverfasser: Edraki, Alireza, Sontheimer, Erik J.
Format: Artikel
Sprache:eng
Schlagworte:
631/326/4041
631/326/41/1969
631/326/41/2529
Biomedical and Life Sciences
Clustered Regularly Interspaced Short Palindromic Repeats
CRISPR
Genome, Bacterial
Genomes
Infectious Diseases
Integration
Life Sciences
Medical Microbiology
Microbiology
News & Views
news-and-views
Parasitology
Sequence Analysis, DNA
Spacer
Virology
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Beschreibung
Zusammenfassung:CRISPR immunity begins with the acquisition of sequences from invading nucleic acids through spacer integration into a CRISPR locus. Off-target integration of spacers into other parts of the genome is now implicated as a spontaneous source of new CRISPR loci.
ISSN:2058-5276
2058-5276
DOI:10.1038/s41564-018-0115-9