Activity of Sphingomyelinase in Rat Liver in Acute and Chronic Toxic Hepatitis: Proportion between Peroxidative and Phospholipase Pathways of Lipid Bilayer Modification

We showed that sphingomyelinase activity in the liver increased only during the acute phase of toxic hepatitis. Peroxidative modification of hepatocyte membrane bilayer prevailed during the acute phase, while after transformation of the process to the chronic phase phospholipase pathway predominated...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2009, Vol.147 (1), p.36-38
Hauptverfasser:	Serebrov, V. Yu, Kuzmenko, D. I., Burov, P. G., Novitsky, S. V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Animals Biomedical and Life Sciences Biomedicine Cell Biology Chemical and Drug Induced Liver Injury - enzymology Chemical and Drug Induced Liver Injury - metabolism Chronic Disease General Pathology and Pathological Physiology Internal Medicine Laboratory Medicine Lipid Bilayers Lipid Peroxidation Liver - enzymology Liver - metabolism Pathology Phospholipase D - metabolism Phospholipases A2 - metabolism Rats Rats, Wistar Sphingomyelin Phosphodiesterase - metabolism
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Zusammenfassung:	We showed that sphingomyelinase activity in the liver increased only during the acute phase of toxic hepatitis. Peroxidative modification of hepatocyte membrane bilayer prevailed during the acute phase, while after transformation of the process to the chronic phase phospholipase pathway predominated.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-009-0456-8