Reinereins A and B, new onocerane triterpenoids from Reinwardtiodendron cinereum

Bioactivity guided separation of Reinwardtiodendron cinereum barks methanol extract led to the isolation of two new onocerane triterpenoids, reinereins A and B ( 1 and 2 ), together with three known onocerane triterpenoids. Their structures were elucidated on the basis of NMR spectroscopic data. In...

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Veröffentlicht in:	Journal of natural medicines 2018-03, Vol.72 (2), p.588-592
Hauptverfasser:	Nugroho, Alfarius Eko, Inoue, Daisuke, Wong, Chin Piow, Hirasawa, Yusuke, Kaneda, Toshio, Shirota, Osamu, Hadi, A. Hamid A., Morita, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Antifungal agents Biomedical and Life Sciences Biomedicine Cancer Complementary & Alternative Medicine Herbal medicine Humans Medicinal Chemistry Meliaceae - chemistry Methanol Molecular Structure Pharmacology/Toxicology Pharmacy Phytochemicals Plant Sciences Triterpenes - chemistry
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Beschreibung
Zusammenfassung:	Bioactivity guided separation of Reinwardtiodendron cinereum barks methanol extract led to the isolation of two new onocerane triterpenoids, reinereins A and B ( 1 and 2 ), together with three known onocerane triterpenoids. Their structures were elucidated on the basis of NMR spectroscopic data. In vitro cytotoxic activities of the isolated compounds against several type of cancer cells were evaluated.
ISSN:	1340-3443 1861-0293
DOI:	10.1007/s11418-018-1188-8