Visible-Light-Induced External Radical-Triggered Annulation To Access CF2‑Containing Benzoxepine Derivatives

Visible-Light-Induced External Radical-Triggered Annulation To Access CF2‑Containing Benzoxepine Derivatives

A facile and diversified synthesis of functionalized CF2-containing benzoxepine derivatives via photoredox catalysis was achieved in this work. This novel protocol features broad substrate scope, mild reaction conditions, operational simplicity, easy scale-up, and versatile derivatization, which wou...

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Veröffentlicht in:Organic letters 2018-03, Vol.20 (5), p.1363-1366
Hauptverfasser: Xiang, Haoyue, Zhao, Qing-Lan, Xia, Peng-Ju, Xiao, Jun-An, Ye, Zhi-Peng, Xie, Xiong, Sheng, Huan, Chen, Xiao-Qing, Yang, Hua
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Sprache:eng
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Zusammenfassung:A facile and diversified synthesis of functionalized CF2-containing benzoxepine derivatives via photoredox catalysis was achieved in this work. This novel protocol features broad substrate scope, mild reaction conditions, operational simplicity, easy scale-up, and versatile derivatization, which would facilitate its practical and broad applications in the construction of valuable and synthetically challenging heterocycles.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.8b00131