Epidemiologic associations of HPV‐positive oropharyngeal cancer and (pre)cancerous cervical lesions

Human papillomavirus (HPV)‐induced oropharyngeal squamous cell carcinoma (OPSCC) remains increasing worldwide. We aimed to investigate if the HPV‐prevalence of OPSCC in the Netherlands is rising as well, also in female patients. In addition, we evaluated the association between HPV‐positive OPSCC an...

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Veröffentlicht in:International journal of cancer 2018-07, Vol.143 (2), p.283-288
Hauptverfasser: Rietbergen, M.M., van Bokhoven, A.A.J.D., Lissenberg‐Witte, B.I., Heideman, D.A.M., Leemans, C.R., Brakenhoff, R.H., Bloemena, E.
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Sprache:eng
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Zusammenfassung:Human papillomavirus (HPV)‐induced oropharyngeal squamous cell carcinoma (OPSCC) remains increasing worldwide. We aimed to investigate if the HPV‐prevalence of OPSCC in the Netherlands is rising as well, also in female patients. In addition, we evaluated the association between HPV‐positive OPSCC and suspicious Pap results of the cervix in these female patients. Patients with OPSCC treated in the period 2000–2015 at the VU University Medical Center Amsterdam, were included (n = 926). The presence of an oncogenic HPV infection was determined by p16‐immunostaining, followed by a high‐risk HPV general primer 5+/6+ DNA PCR on the p16‐immunopositive cases. A review of pathology reports in all female patients (n = 305) was undertaken to identify cytological signs of HPV‐related (pre)cancer of the cervix. In total 281 of 926 (30.3%) OPSCCs were HPV‐positive. Moreover, a significant increase in the prevalence of HPV‐positive OPSCCs was observed from 14.0% in 2000 to 48.1% in 2015 (p 
ISSN:0020-7136
1097-0215
1097-0215
DOI:10.1002/ijc.31315