Association between IgH enhancer hs1.2 and type 1 diabetes

Association between IgH enhancer hs1.2 and type 1 diabetes

Aim To investigate the association of alleles of the 3′ immunoglobulin heavy-chain regulatory region 1 (3′RR-1) enhancer hs1.2 in patients with type 1 diabetes (T1D). Methods Eighty-one patients with T1D [among which 12 had concomitant coeliac disease (CD) and 25 an autoimmune thyroid disease (AITD)...

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Veröffentlicht in:Acta diabetologica 2018-05, Vol.55 (5), p.443-448
Hauptverfasser: Cianci, Rossella, D’Addabbo, Pietro, Gambassi, Giovanni, Lolli, Serena, Serone, Eliseo, Rizzi, Alessandro, Pitocco, Dario, Pandolfi, Franco, Frezza, Domenico
Format: Artikel
Sprache:eng
Schlagworte:
Alleles
Autoimmune diseases
Celiac disease
Diabetes
Diabetes mellitus
Diabetes mellitus (insulin dependent)
Gene frequency
Heavy chains
Immunoglobulins
Immunological diseases
Internal Medicine
Medicine
Medicine & Public Health
Metabolic Diseases
Original Article
Thyroid
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Zusammenfassung:Aim To investigate the association of alleles of the 3′ immunoglobulin heavy-chain regulatory region 1 (3′RR-1) enhancer hs1.2 in patients with type 1 diabetes (T1D). Methods Eighty-one patients with T1D [among which 12 had concomitant coeliac disease (CD) and 25 an autoimmune thyroid disease (AITD)] were compared to 248 healthy individuals. All subjects were recruited from the same geographical area. Blood samples were collected from all patients and a nested PCR was performed to amplify the core of the 3′RR-1 and detect the alleles of the hs1.2 enhancer. Results Allele distribution in healthy individuals was significantly different when compared to that of patients with T1D ( p  
ISSN:0940-5429
1432-5233
DOI:10.1007/s00592-018-1103-5