MOG-antibody demyelinating diseases: a case of post-partum severe rhombencephalitis and transverse myelitis

Myelin oligodendrocyte glycoprotein antibodies (MOG-IgG) associated disorders present with a spectrum of clinical pictures including brainstem involvement. A patient with the sudden onset of a post-partum severe rhombencephalitis causing respiratory failure (12 years after a mild transverse myelitis). Despite the aggressive clinical course, she had an impressive recovery after plasmapheresis, and no further relapses on immunosuppression. MOG-IgG disorders could relapse several years after onset and involve brainstem. Good prognosis is possible after treatment. •MOG-IgG disorders are a clinical spectrum that could involve brainstem.•Rhombencephalitis (with transverse myelitis) could be caused by MOG-IgG.•Patients with MOG-IgG disorder could recover massively from severe attacks.