Copper(ii)-mediated, carbon degradation-based amidation of phenylacetic acids toward N-substituted benzamides

Copper(ii)-mediated, carbon degradation-based amidation of phenylacetic acids toward N-substituted benzamides

The unprecedented synthesis of N-aryl substituted benzamides via the assembly of primary amines and phenylacetic acids has been developed in the presence of copper(ii) acetate. This tandem transformation involving carbon-carbon bond cleavage provides a complementary tool with particular application...

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Veröffentlicht in:Organic & biomolecular chemistry 2018-03, Vol.16 (9), p.1552-1556
Hauptverfasser: Deng, Leiling, Huang, Bin, Liu, Yunyun
Format: Artikel
Sprache:eng
Schlagworte:
Acetic acid
Acids
Amines
Aromatic compounds
Carbon
Copper
Copper acetate
Copper compounds
Substitutes
Synthesis
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Beschreibung
Zusammenfassung:The unprecedented synthesis of N-aryl substituted benzamides via the assembly of primary amines and phenylacetic acids has been developed in the presence of copper(ii) acetate. This tandem transformation involving carbon-carbon bond cleavage provides a complementary tool with particular application in the synthesis of secondary benzamides.
ISSN:1477-0520
1477-0539
DOI:10.1039/c8ob00064f