Iridium(I)-Catalyzed Alkylation Reactions To Form α‑Alkylated Ketones

A highly effective and green procedure for the formation of α-alkylated ketones has been disclosed via the reaction of primary alcohols with secondary alcohols and ketones by using [IrCl­(COD)­(NHC)] complexes as a catalyst. Various α-alkylated ketones were obtained in high yields from the alkylation of alcohol with alcohol and ketone with alcohol through a borrowing hydrogen reaction by using 0.05–0.5 mol % iridium­(I) and a catalytic amount of KOH (5–10 mol %) as the base under air atmosphere and within very short reaction times.