A Xanthocillin-like Alkaloid from the Insect Pathogenic Fungus Cordyceps brunnearubra BCC 1395

A Xanthocillin-like Alkaloid from the Insect Pathogenic Fungus Cordyceps brunnearubra BCC 1395

Cordyformamide (4), the plausible biogenetic precursor of xanthocillin Y2, was isolated from a culture broth of the insect pathogenic fungus Cordyceps brunnearubra BCC 1395. Cordyformamide was found to exhibit activity against the malarial parasite Plasmodium falciparum K1 with an IC50 value of 18 μ...

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Veröffentlicht in:Journal of natural products (Washington, D.C.) D.C.), 2007-04, Vol.70 (4), p.656-658
Hauptverfasser: Isaka, Masahiko, Boonkhao, Bundit, Rachtawee, Pranee, Auncharoen, Patchanee
Format: Artikel
Sprache:eng
Schlagworte:
alkaloids
Alkaloids - chemistry
Alkaloids - isolation & purification
Alkaloids - pharmacology
Animals
antimalarials
Antimalarials - chemistry
Antimalarials - isolation & purification
Antimalarials - pharmacology
Biological and medical sciences
Butadienes - chemistry
Butadienes - isolation & purification
Butadienes - pharmacology
chemical structure
Cordyceps
Cordyceps - chemistry
Cordyceps brunnearubra
cordyformamide
cyanides
entomopathogenic fungi
General pharmacology
human health
Humans
Inhibitory Concentration 50
Insecta - microbiology
KB Cells
Medical sciences
medicinal properties
Molecular Structure
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phenols - chemistry
Phenols - isolation & purification
Phenols - pharmacology
Plasmodium falciparum
Plasmodium falciparum - drug effects
spectral analysis
xanthocillin
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Zusammenfassung:Cordyformamide (4), the plausible biogenetic precursor of xanthocillin Y2, was isolated from a culture broth of the insect pathogenic fungus Cordyceps brunnearubra BCC 1395. Cordyformamide was found to exhibit activity against the malarial parasite Plasmodium falciparum K1 with an IC50 value of 18 μM, whereas it showed weak or no cytotoxicity.
ISSN:0163-3864
1520-6025
DOI:10.1021/np060509t