Clerodens E–J, antibacterial caffeic acid derivatives from the aerial part of Clerodendranthus spicatus

Six new caffeic acid derivatives, Clerodens E–J (1–6) were isolated from the aerial part of Clerodendranthus spicatus. Their structures were elucidated by extensive spectroscopic analysis, including NMR, MS, and ECD data. Compound 1 showed moderate antibacterial activities against drug-resistant str...

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Veröffentlicht in:	Fitoterapia 2016-10, Vol.114, p.110-114
Hauptverfasser:	Li, Qing, He, Ying-Na, Shi, Xiao-Wei, Kang, Li-Ying, Niu, Li-Ying, Wang, Xin-Guo, Feng, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	aerial parts Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification antibacterial properties bacteria Bacteria - drug effects caffeic acid Caffeic acid derivatives Caffeic Acids - chemistry Caffeic Acids - isolation & purification Clerodendranthus spicatus Clerodens E–J drug resistance Drug Resistance, Bacterial Lamiaceae - chemistry medicinal plants Microbial Sensitivity Tests Molecular Structure nuclear magnetic resonance spectroscopy Orthosiphon aristatus Plant Components, Aerial - chemistry
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Zusammenfassung:	Six new caffeic acid derivatives, Clerodens E–J (1–6) were isolated from the aerial part of Clerodendranthus spicatus. Their structures were elucidated by extensive spectroscopic analysis, including NMR, MS, and ECD data. Compound 1 showed moderate antibacterial activities against drug-resistant strains of bacteria in vitro. [Display omitted]
ISSN:	0367-326X 1873-6971
DOI:	10.1016/j.fitote.2016.08.021