Topoisomerase IIα Expression as an Independent Prognostic Factor in Hodgkin's Lymphoma
Purpose: To correlate the immunohistochemical expression of topoisomerase IIα (topoIIα) in Hodgkin's lymphoma (HL) with clinicopathological parameters, the expression of Ki-67 and the outcome of patients, who had been homogenously treated with ABVD or equivalent regimens. Experimental Design: I...
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Veröffentlicht in: | Clinical cancer research 2008-03, Vol.14 (6), p.1759-1766 |
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Zusammenfassung: | Purpose: To correlate the immunohistochemical expression of topoisomerase IIα (topoIIα) in Hodgkin's lymphoma (HL) with clinicopathological
parameters, the expression of Ki-67 and the outcome of patients, who had been homogenously treated with ABVD or equivalent
regimens.
Experimental Design: Immunohistochemistry using the monoclonal antibody Ki-S1 (topoIIα) was performed in 238 HL patients. MiB1 (Ki-67) expression
was evaluated in 211/238.
Results: The mean ± SD percentage of topoIIα- and Ki-67–positive Hodgkin-Reed-Sternberg (HRS) cells was 63 ± 19% (5%-98%) and 73 ±
19% (8%-99%), respectively. The median percentage of topoIIα-positive HRS cells was 64% (interquartile range, 51-78%). There
was no correlation between topoIIα expression and patient characteristics. TopoIIα and Ki-67 expression were correlated (Spearman's
Rho 0.255, P < 0.001). TopoIlα expression within the highest quartile of this patient population was predictive of failure free survival
(FFS) (10-year rates 82 ± 3% vs 68 ± 7%, P = 0.02 for patients falling into the quartiles 1-3 and 4 respectively). In multivariate analysis topoIIα expression was independently
predictive of FFS.
Conclusion: TopoIIα was expressed in all cases of HL showing a correlation with Ki-67 expression. Under current standard therapy including
drugs inhibiting its activity, topoIIα was an independent adverse predictor of FFS with no statistically significant correlation
with other established prognostic factors. |
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ISSN: | 1078-0432 1557-3265 |
DOI: | 10.1158/1078-0432.CCR-07-1395 |