Effect of oil and co-surfactant on the formation of Solutol HS 15 based colloidal drug carrier by Box–Behnken statistical design

•Phase diagram was constructed to understand the phase behavior of components.•Different regions in phase diagram were assessed by calibration plot technique.•Sefsol 218 as oil shows maximum water solubilization capacity for Solutol HS 15.•Km 2:1 has distinct influence on emulsification of Sefsol 21...

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Veröffentlicht in:Colloids and surfaces. A, Physicochemical and engineering aspects Physicochemical and engineering aspects, 2014-07, Vol.453, p.68-77
Hauptverfasser: Ahmad, Javed, Mir, Showkat R., Kohli, Kanchan, Amin, Saima
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Sprache:eng
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Zusammenfassung:•Phase diagram was constructed to understand the phase behavior of components.•Different regions in phase diagram were assessed by calibration plot technique.•Sefsol 218 as oil shows maximum water solubilization capacity for Solutol HS 15.•Km 2:1 has distinct influence on emulsification of Sefsol 218 containing Paclitaxel.•Optimized composition gets self emulsified to form drug carrier of
ISSN:0927-7757
1873-4359
DOI:10.1016/j.colsurfa.2014.04.008