High urinary interleukin‐8 levels is associated with poor prognosis in idiopathic membranous nephropathy

High urinary interleukin‐8 levels is associated with poor prognosis in idiopathic membranous nephropathy

Biomarkers required to assess accurately the prognosis of idiopathic membranous nephropathy (IMN) are still unavailable. A retrospective study on 156 IMN patients showed only urinary IL‐8 was associated with the achievement of initial complete remission (CR) in IMN patients. A urinary IL‐8 level of...

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Veröffentlicht in:Internal medicine journal 2018-02, Vol.48 (2), p.207-209
Hauptverfasser: Chen, Jilin, Fu, Xiaoye, Sun, Yanling, Zhang, Shengkun, Xie, Hua, Lin, Hongli
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Biomarkers - urine
Cohort Studies
cytokines
Female
Glomerulonephritis, Membranous - diagnosis
Glomerulonephritis, Membranous - urine
Humans
idiopathic membranous nephropathy
Interleukin 8
Interleukin-8 - urine
Male
Membranous nephropathy
Middle Aged
Nephropathy
Prognosis
Remission
Retrospective Studies
Young Adult
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Zusammenfassung:Biomarkers required to assess accurately the prognosis of idiopathic membranous nephropathy (IMN) are still unavailable. A retrospective study on 156 IMN patients showed only urinary IL‐8 was associated with the achievement of initial complete remission (CR) in IMN patients. A urinary IL‐8 level of less than 61.25 pg/mL was more sensitive for prediction of CR in IMN patients. Therefore, urinary IL‐8 may be a potential biomarker for evaluating short‐term prognosis of IMN patients.
ISSN:1444-0903
1445-5994
DOI:10.1111/imj.13698