Microbial Metalloproteinases Mediate Sensing of Invading Pathogens and Activate Innate Immune Responses in the Lepidopteran Model Host Galleria mellonella

Microbial Metalloproteinases Mediate Sensing of Invading Pathogens and Activate Innate Immune Responses in the Lepidopteran Model Host Galleria mellonella

Thermolysin-like metalloproteinases such as aureolysin, pseudolysin, and bacillolysin represent virulence factors of diverse bacterial pathogens. Recently, we discovered that injection of thermolysin into larvae of the greater wax moth, Galleria mellonella, mediated strong immune responses. Thermoly...

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Veröffentlicht in:Infection and Immunity 2007-01, Vol.75 (1), p.175-183
Hauptverfasser: Altincicek, Boran, Linder, Monica, Linder, Dietmar, Preissner, Klaus T, Vilcinskas, Andreas
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biological and medical sciences
Cryptococcus neoformans
Electrophoresis, Gel, Two-Dimensional
Enzyme Activation
Fundamental and applied biological sciences. Psychology
Galleria mellonella
Gene Expression
Hemolymph - immunology
Hemolymph - metabolism
Host Response and Inflammation
Immunity, Innate
Larva
Lepidoptera
Lepidoptera - immunology
Lepidoptera - microbiology
Lipopolysaccharides - immunology
Metalloendopeptidases - immunology
Metalloendopeptidases - metabolism
Microbiology
Models, Immunological
Oligopeptides - immunology
Oligopeptides - metabolism
Reverse Transcriptase Polymerase Chain Reaction
Serine Endopeptidases - immunology
Serine Endopeptidases - metabolism
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Thermolysin - immunology
Thermolysin - metabolism
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Zusammenfassung:Thermolysin-like metalloproteinases such as aureolysin, pseudolysin, and bacillolysin represent virulence factors of diverse bacterial pathogens. Recently, we discovered that injection of thermolysin into larvae of the greater wax moth, Galleria mellonella, mediated strong immune responses. Thermolysin-mediated proteolysis of hemolymph proteins yielded a variety of small-sized (
ISSN:0019-9567
1098-5522
DOI:10.1128/IAI.01385-06