Synthesis and antibacterial activity of C sub(12) des-methyl ketolides

Synthesis and antibacterial activity of C sub(12) des-methyl ketolides

Synthesis of C sub(12) des-methyl ketolide is developed featuring an intramolecular epoxide formation/elimination process to establish the C sub(12) stereocenter. These ketolides are potent against several key respiratory pathogens, including erythromycin resistant erm- and mef-containing strains of...

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Veröffentlicht in:Bioorganic & medicinal chemistry letters 2006-09, Vol.16 (17), p.4692-4696
Hauptverfasser: Lin, Xiaodong, Rico, Alice C, Chu, Daniel T, Carroll, Georgia L, Barker, Lynn, Shawar, Ribhi, Desai, Manoj C, Plattner, Jacob J
Format: Artikel
Sprache:eng
Schlagworte:
Streptococcus pneumoniae
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Zusammenfassung:Synthesis of C sub(12) des-methyl ketolide is developed featuring an intramolecular epoxide formation/elimination process to establish the C sub(12) stereocenter. These ketolides are potent against several key respiratory pathogens, including erythromycin resistant erm- and mef-containing strains of Streptococcus pneumoniae.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2006.05.104