Effect of mannan oligosaccharides on the performance, intestinal morphology and cecal fermentation of fattening rabbits

A common problem in rabbits is the occurrence of digestive disorders just after weaning. This problem is associated with instability of the cecal microflora and characterized by diarrhea, loss of appetite and increased mortality. In the current study the effects of mannan oligosaccharide (MOS, Bio-Mos ®, Alltech Inc., USA), a natural growth promoter, were compared to a commonly used antibiotic growth promoter (AGP, Zn-Bacitracin). The five experimental treatments were as follow: Control (no additives); MOS 1 (Bio-Mos ®, 1 g kg −1); MOS 1.5 (Bio-Mos ®, 1.5 g kg −1); MOS 2 (Bio-Mos ®, 2 g kg −1) and AGP (Zn-Bacitracin; 0.1 g kg −1). Experimental diets were based on alfalfa, sunflower meal, wheat and beet pulp and were offered ad libitum through out the experiment. Trial 1 used 400 weaned mixed-sex rabbits divided into the five treatments with 10 replicates and 8 rabbits/replicate. Rabbits were weighed at weaning (day 32) and at the end of the experiment (day 67). Weight gain, feed intake, feed conversion ratio (FCR) and mortality were evaluated using a commercial grow-out facility. Trial 2 used 220 weaned rabbits divided into the same five experimental treatment groups and housed in groups of 4 in 11 flat deck cages located in an experimental rabbit house. In trial 2 performance, intestinal morphology and cecal fermentation were determined. In both trials, rabbit daily weight gain and feed intake were not affected by treatments. However, in trial 1 MOS rabbits had better (P