Structural Identification of the Nicotinic Receptor Ion Channel

The structural identification of the cationic channel of the acetylcholine nicotinic receptor involved its biochemical tagging by channel blockers, followed by site-directed mutagenesis analyses reported in two papers in 1988. The ion channel was demonstrated to be lined by the transmembrane segment...

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Veröffentlicht in:	Trends in neurosciences (Regular ed.) 2018-02, Vol.41 (2), p.67-70
1. Verfasser:	Changeux, Jean-Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Humans Ion Channels - chemistry Ion Channels - genetics ionic channel structure Mutation - genetics Nicotinic Agonists - pharmacology nicotinic receptor pentameric receptors Receptors, Nicotinic - chemistry Receptors, Nicotinic - genetics
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