Structural Identification of the Nicotinic Receptor Ion Channel

The structural identification of the cationic channel of the acetylcholine nicotinic receptor involved its biochemical tagging by channel blockers, followed by site-directed mutagenesis analyses reported in two papers in 1988. The ion channel was demonstrated to be lined by the transmembrane segment...

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Veröffentlicht in:	Trends in neurosciences (Regular ed.) 2018-02, Vol.41 (2), p.67-70
1. Verfasser:	Changeux, Jean-Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Humans Ion Channels - chemistry Ion Channels - genetics ionic channel structure Mutation - genetics Nicotinic Agonists - pharmacology nicotinic receptor pentameric receptors Receptors, Nicotinic - chemistry Receptors, Nicotinic - genetics
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	The structural identification of the cationic channel of the acetylcholine nicotinic receptor involved its biochemical tagging by channel blockers, followed by site-directed mutagenesis analyses reported in two papers in 1988. The ion channel was demonstrated to be lined by the transmembrane segment MII, in which the binding sites of channel blockers are “framed” by anionic rings.
ISSN:	0166-2236 1878-108X
DOI:	10.1016/j.tins.2017.11.003