Structural Identification of the Nicotinic Receptor Ion Channel
The structural identification of the cationic channel of the acetylcholine nicotinic receptor involved its biochemical tagging by channel blockers, followed by site-directed mutagenesis analyses reported in two papers in 1988. The ion channel was demonstrated to be lined by the transmembrane segment...
Gespeichert in:
| Veröffentlicht in: | Trends in neurosciences (Regular ed.) 2018-02, Vol.41 (2), p.67-70 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 70 |
|---|---|
| container_issue | 2 |
| container_start_page | 67 |
| container_title | Trends in neurosciences (Regular ed.) |
| container_volume | 41 |
| creator | Changeux, Jean-Pierre |
| description | The structural identification of the cationic channel of the acetylcholine nicotinic receptor involved its biochemical tagging by channel blockers, followed by site-directed mutagenesis analyses reported in two papers in 1988. The ion channel was demonstrated to be lined by the transmembrane segment MII, in which the binding sites of channel blockers are “framed” by anionic rings. |
| doi_str_mv | 10.1016/j.tins.2017.11.003 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1995166420</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0166223617302254</els_id><sourcerecordid>1995166420</sourcerecordid><originalsourceid>FETCH-LOGICAL-c422t-9ab14a0ebe8cf1841241c52959ba32469e648376016c98655ff8555f8dd539443</originalsourceid><addsrcrecordid>eNp9kE1LAzEQhoMotlb_gAfZo5ddM9nsNgFBpPhRKAp-gLeQzc7SlO1uTbKC_96UVo9eMoc8887MQ8g50AwolFerLNjOZ4zCNAPIKM0PyBjEVKRAxcchGUeoTBnLyxE58X5FKXAB_JiMmOS0kEyMyc1rcIMJg9NtMq-xC7axRgfbd0nfJGGJyZM1fZxjTfKCBjehd8k8_s6WuuuwPSVHjW49nu3rhLzf373NHtPF88N8drtIDWcspFJXwDXFCoVpQHBgHEzBZCErnTNeSiy5yKdl3NhIURZF04givqKui1xynk_I5S534_rPAX1Qa-sNtq3usB-8AimLeC1nNKJshxrXe--wURtn19p9K6BqK06t1Fac2opTACqKi00X-_yhWmP91_JrKgLXOwDjlV8WnfLGYmewtg5NUHVv_8v_AeYDfZY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1995166420</pqid></control><display><type>article</type><title>Structural Identification of the Nicotinic Receptor Ion Channel</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Changeux, Jean-Pierre</creator><creatorcontrib>Changeux, Jean-Pierre</creatorcontrib><description>The structural identification of the cationic channel of the acetylcholine nicotinic receptor involved its biochemical tagging by channel blockers, followed by site-directed mutagenesis analyses reported in two papers in 1988. The ion channel was demonstrated to be lined by the transmembrane segment MII, in which the binding sites of channel blockers are “framed” by anionic rings.</description><identifier>ISSN: 0166-2236</identifier><identifier>EISSN: 1878-108X</identifier><identifier>DOI: 10.1016/j.tins.2017.11.003</identifier><identifier>PMID: 29405928</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Humans ; Ion Channels - chemistry ; Ion Channels - genetics ; ionic channel structure ; Mutation - genetics ; Nicotinic Agonists - pharmacology ; nicotinic receptor ; pentameric receptors ; Receptors, Nicotinic - chemistry ; Receptors, Nicotinic - genetics</subject><ispartof>Trends in neurosciences (Regular ed.), 2018-02, Vol.41 (2), p.67-70</ispartof><rights>2017 Elsevier Ltd</rights><rights>Copyright © 2017 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-9ab14a0ebe8cf1841241c52959ba32469e648376016c98655ff8555f8dd539443</citedby><cites>FETCH-LOGICAL-c422t-9ab14a0ebe8cf1841241c52959ba32469e648376016c98655ff8555f8dd539443</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.tins.2017.11.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29405928$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Changeux, Jean-Pierre</creatorcontrib><title>Structural Identification of the Nicotinic Receptor Ion Channel</title><title>Trends in neurosciences (Regular ed.)</title><addtitle>Trends Neurosci</addtitle><description>The structural identification of the cationic channel of the acetylcholine nicotinic receptor involved its biochemical tagging by channel blockers, followed by site-directed mutagenesis analyses reported in two papers in 1988. The ion channel was demonstrated to be lined by the transmembrane segment MII, in which the binding sites of channel blockers are “framed” by anionic rings.</description><subject>Animals</subject><subject>Humans</subject><subject>Ion Channels - chemistry</subject><subject>Ion Channels - genetics</subject><subject>ionic channel structure</subject><subject>Mutation - genetics</subject><subject>Nicotinic Agonists - pharmacology</subject><subject>nicotinic receptor</subject><subject>pentameric receptors</subject><subject>Receptors, Nicotinic - chemistry</subject><subject>Receptors, Nicotinic - genetics</subject><issn>0166-2236</issn><issn>1878-108X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMotlb_gAfZo5ddM9nsNgFBpPhRKAp-gLeQzc7SlO1uTbKC_96UVo9eMoc8887MQ8g50AwolFerLNjOZ4zCNAPIKM0PyBjEVKRAxcchGUeoTBnLyxE58X5FKXAB_JiMmOS0kEyMyc1rcIMJg9NtMq-xC7axRgfbd0nfJGGJyZM1fZxjTfKCBjehd8k8_s6WuuuwPSVHjW49nu3rhLzf373NHtPF88N8drtIDWcspFJXwDXFCoVpQHBgHEzBZCErnTNeSiy5yKdl3NhIURZF04givqKui1xynk_I5S534_rPAX1Qa-sNtq3usB-8AimLeC1nNKJshxrXe--wURtn19p9K6BqK06t1Fac2opTACqKi00X-_yhWmP91_JrKgLXOwDjlV8WnfLGYmewtg5NUHVv_8v_AeYDfZY</recordid><startdate>201802</startdate><enddate>201802</enddate><creator>Changeux, Jean-Pierre</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201802</creationdate><title>Structural Identification of the Nicotinic Receptor Ion Channel</title><author>Changeux, Jean-Pierre</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-9ab14a0ebe8cf1841241c52959ba32469e648376016c98655ff8555f8dd539443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>Humans</topic><topic>Ion Channels - chemistry</topic><topic>Ion Channels - genetics</topic><topic>ionic channel structure</topic><topic>Mutation - genetics</topic><topic>Nicotinic Agonists - pharmacology</topic><topic>nicotinic receptor</topic><topic>pentameric receptors</topic><topic>Receptors, Nicotinic - chemistry</topic><topic>Receptors, Nicotinic - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Changeux, Jean-Pierre</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Trends in neurosciences (Regular ed.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Changeux, Jean-Pierre</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Structural Identification of the Nicotinic Receptor Ion Channel</atitle><jtitle>Trends in neurosciences (Regular ed.)</jtitle><addtitle>Trends Neurosci</addtitle><date>2018-02</date><risdate>2018</risdate><volume>41</volume><issue>2</issue><spage>67</spage><epage>70</epage><pages>67-70</pages><issn>0166-2236</issn><eissn>1878-108X</eissn><abstract>The structural identification of the cationic channel of the acetylcholine nicotinic receptor involved its biochemical tagging by channel blockers, followed by site-directed mutagenesis analyses reported in two papers in 1988. The ion channel was demonstrated to be lined by the transmembrane segment MII, in which the binding sites of channel blockers are “framed” by anionic rings.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>29405928</pmid><doi>10.1016/j.tins.2017.11.003</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0166-2236 |
| ispartof | Trends in neurosciences (Regular ed.), 2018-02, Vol.41 (2), p.67-70 |
| issn | 0166-2236 1878-108X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1995166420 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Humans Ion Channels - chemistry Ion Channels - genetics ionic channel structure Mutation - genetics Nicotinic Agonists - pharmacology nicotinic receptor pentameric receptors Receptors, Nicotinic - chemistry Receptors, Nicotinic - genetics |
| title | Structural Identification of the Nicotinic Receptor Ion Channel |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T10%3A35%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Structural%20Identification%20of%20the%20Nicotinic%20Receptor%20Ion%20Channel&rft.jtitle=Trends%20in%20neurosciences%20(Regular%20ed.)&rft.au=Changeux,%20Jean-Pierre&rft.date=2018-02&rft.volume=41&rft.issue=2&rft.spage=67&rft.epage=70&rft.pages=67-70&rft.issn=0166-2236&rft.eissn=1878-108X&rft_id=info:doi/10.1016/j.tins.2017.11.003&rft_dat=%3Cproquest_cross%3E1995166420%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1995166420&rft_id=info:pmid/29405928&rft_els_id=S0166223617302254&rfr_iscdi=true |