Population structure of Streptococcus pneumoniae colonizing children before and after universal use of pneumococcal conjugate vaccines in Brazil: emergence and expansion of the MDR serotype 6C-CC386 lineage

To determine the population structure and change in drug resistance of pneumococci colonizing children before and after the introduction of the 10-valent and 13-valent pneumococcal conjugate vaccines (PCV10/13) in Brazil. We used MLST to analyse 256 pneumococcal isolates obtained from children aged...

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Veröffentlicht in:Journal of antimicrobial chemotherapy 2018-05, Vol.73 (5), p.1206-1212
Hauptverfasser: Neves, Felipe P G, Cardoso, Nayara T, Souza, Aline R V, Snyder, Robert E, Marlow, Mariel M, Pinto, Tatiana C A, Teixeira, Lúcia M, Riley, Lee W
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Sprache:eng
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Zusammenfassung:To determine the population structure and change in drug resistance of pneumococci colonizing children before and after the introduction of the 10-valent and 13-valent pneumococcal conjugate vaccines (PCV10/13) in Brazil. We used MLST to analyse 256 pneumococcal isolates obtained from children aged 256 mg/L) in the post-PCV10/13 period. Although PNSP strains were polyclonal, most resistant isolates belonged to a single genotype from each period. Higher erythromycin resistance prevalence (42%) in the post-PCV10/13 period was mainly attributed to MDR serotype 6C-CC386. Ongoing surveillance of pneumococcal clonal composition is important to evaluate PCV use outcomes and to identify factors other than PCVs that drive pneumococcal drug resistance evolution.
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/dky001