Population structure of Streptococcus pneumoniae colonizing children before and after universal use of pneumococcal conjugate vaccines in Brazil: emergence and expansion of the MDR serotype 6C-CC386 lineage
To determine the population structure and change in drug resistance of pneumococci colonizing children before and after the introduction of the 10-valent and 13-valent pneumococcal conjugate vaccines (PCV10/13) in Brazil. We used MLST to analyse 256 pneumococcal isolates obtained from children aged...
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Veröffentlicht in: | Journal of antimicrobial chemotherapy 2018-05, Vol.73 (5), p.1206-1212 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | To determine the population structure and change in drug resistance of pneumococci colonizing children before and after the introduction of the 10-valent and 13-valent pneumococcal conjugate vaccines (PCV10/13) in Brazil.
We used MLST to analyse 256 pneumococcal isolates obtained from children aged 256 mg/L) in the post-PCV10/13 period.
Although PNSP strains were polyclonal, most resistant isolates belonged to a single genotype from each period. Higher erythromycin resistance prevalence (42%) in the post-PCV10/13 period was mainly attributed to MDR serotype 6C-CC386. Ongoing surveillance of pneumococcal clonal composition is important to evaluate PCV use outcomes and to identify factors other than PCVs that drive pneumococcal drug resistance evolution. |
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ISSN: | 0305-7453 1460-2091 |
DOI: | 10.1093/jac/dky001 |