Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases

Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases

Clinical measurements can be viewed as useful intermediate phenotypes to promote understanding of complex human diseases. To acquire comprehensive insights into the underlying genetics, here we conducted a genome-wide association study (GWAS) of 58 quantitative traits in 162,255 Japanese individuals...

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Veröffentlicht in:Nature genetics 2018-03, Vol.50 (3), p.390-400
Hauptverfasser: Kanai, Masahiro, Akiyama, Masato, Takahashi, Atsushi, Matoba, Nana, Momozawa, Yukihide, Ikeda, Masashi, Iwata, Nakao, Ikegawa, Shiro, Hirata, Makoto, Matsuda, Koichi, Kubo, Michiaki, Okada, Yukinori, Kamatani, Yoichiro
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Sprache:eng
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Agriculture
Animal Genetics and Genomics
Bioinformatics
Biology
Biomedical and Life Sciences
Biomedicine
Blood pressure
Cancer Research
Consortia
Diseases
Etiology
Gene Function
Genetic analysis
Genetics
Genome-wide association studies
Genomes
Genotype & phenotype
Human Genetics
Metabolism
Pathogenesis
Phenotypes
Pleiotropy
Polygenic inheritance
Studies
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Beschreibung
Zusammenfassung:Clinical measurements can be viewed as useful intermediate phenotypes to promote understanding of complex human diseases. To acquire comprehensive insights into the underlying genetics, here we conducted a genome-wide association study (GWAS) of 58 quantitative traits in 162,255 Japanese individuals. Overall, we identified 1,407 trait-associated loci ( P  
ISSN:1061-4036
1546-1718
DOI:10.1038/s41588-018-0047-6