Impact of Clinical and Laboratory Standards Institute breakpoint changes on susceptibility rates of cephalosporins in uncomplicated urinary tract infections caused by Enterobacteriaceae

Breakpoint changes may impact cephalosporin susceptibility rates in uncomplicated urinary tract infections (uUTIs). Applying the ≤16-mg/L breakpoint to urine cultures from adult women in an academic health system resulted in cefazolin being the most active uUTI antimicrobial, with 86.9% susceptibility, compared to levofloxacin (80%), nitrofurantoin (76.5%), and sulfamethoxazole-trimethoprim (72.6%). •Cefazolin susceptibility against urinary Enterobacteriaceae is higher at ≤16mg/L than ≤4mg/L.•Cefazolin is the most active antimicrobial (> 85%) for urinary Enterobacteriaceae at a single center.•Cephalosporins may be an appropriate empiric therapy for uncomplicated UTI.