Higher level of GGT during mid‐pregnancy is associated with increased risk of gestational diabetes mellitus

Summary Objective This study was to explore the link between gamma‐glutamyl transferase (GGT), alanine transaminase (ALT) and aspartate transaminase (AST) levels during early‐middle pregnancy and subsequent risk of gestational diabetes mellitus (GDM). Methods In a prospective cohort study, pregnant women enrolled prior to 16 weeks of gestation were followed up until delivery. GGT, AST and ALT levels were tested during weeks 14‐18 of gestation and oral glucose tolerance test was conducted during 24‐28 weeks to screen GDM. Results The GDM rate was 8.1% (122/1512). Mean GGT level was higher in GDM than non‐GDM women (18.7 ± 13.0 vs 14.5 ± 7.0, P 26.9 U/L may indicate an increased risk of developing GDM later and should be further concerned.