Vancomycin–impregnated electrospun polycaprolactone (PCL) membrane for the treatment of infected bone defects: An animal study

There is no consensus for the management of critical infected bone defects. The purpose of this study was to produce a vancomycin–impregnated electrospun polycaprolactone (PCL) membrane for the treatment of infected critical bone defects, and test it in a rabbit model. Electrospinning produced a res...

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Veröffentlicht in:	Journal of biomaterials applications 2018-04, Vol.32 (9), p.1187-1196
Hauptverfasser:	Wei, Shijun, Jian, Chao, Xu, Feng, Bao, Tongzhu, Lan, Shenghui, Wu, Gang, Qi, BaiWen, Bai, Zikui, Yu, Aixi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - therapeutic use Bone and Bones - microbiology Bone and Bones - pathology Drug Delivery Systems Male Membranes, Artificial Osteomyelitis - drug therapy Osteomyelitis - microbiology Osteomyelitis - pathology Polyesters - chemistry Rabbits Staphylococcal Infections - drug therapy Staphylococcal Infections - microbiology Staphylococcal Infections - pathology Staphylococcus aureus - drug effects Vancomycin - administration & dosage Vancomycin - therapeutic use
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Zusammenfassung:	There is no consensus for the management of critical infected bone defects. The purpose of this study was to produce a vancomycin–impregnated electrospun polycaprolactone (PCL) membrane for the treatment of infected critical bone defects, and test it in a rabbit model. Electrospinning produced a resorbable PCL fiber membrane containing vancomycin approximately 1 mm in thickness, with a pore diameter of
ISSN:	0885-3282 1530-8022
DOI:	10.1177/0885328218754462