Photon vs. proton radiochemotherapy: Effects on brain tissue volume and perfusion

To compare the structural and hemodynamic changes of healthy brain tissue in the cerebral hemisphere contralateral to the tumor following photon and proton radiochemotherapy. Sixty-seven patients (54.9 ±14.0 years) diagnosed with glioblastoma undergoing adjuvant photon (n = 47) or proton (n = 19) ra...

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Veröffentlicht in:	Radiotherapy and oncology 2018-07, Vol.128 (1), p.121-127
Hauptverfasser:	Petr, Jan, Platzek, Ivan, Hofheinz, Frank, Mutsaerts, Henri J.M.M., Asllani, Iris, van Osch, Matthias J.P., Seidlitz, Annekatrin, Krukowski, Pawel, Gommlich, Andreas, Beuthien-Baumann, Bettina, Jentsch, Christina, Maus, Jens, Troost, Esther G.C., Baumann, Michael, Krause, Mechthild, van den Hoff, Jörg
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antineoplastic Agents, Alkylating - therapeutic use Arterial spin labeling Brain - blood supply Brain - pathology Brain - radiation effects Brain atrophy Brain Neoplasms - drug therapy Brain Neoplasms - pathology Brain Neoplasms - radiotherapy Cerebral blood flow Cerebrovascular Circulation - radiation effects Chemoradiotherapy - adverse effects Chemoradiotherapy - methods Dacarbazine - analogs & derivatives Dacarbazine - therapeutic use Female Glioblastoma - drug therapy Glioblastoma - pathology Glioblastoma - radiotherapy Gray Matter - radiation effects Humans Magnetic Resonance Imaging - methods Male Middle Aged Multivariate Analysis Photons - adverse effects Photons - therapeutic use Proton beam therapy Proton Therapy - adverse effects Radiochemotherapy Temozolomide White Matter - radiation effects Young Adult
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Zusammenfassung:	To compare the structural and hemodynamic changes of healthy brain tissue in the cerebral hemisphere contralateral to the tumor following photon and proton radiochemotherapy. Sixty-seven patients (54.9 ±14.0 years) diagnosed with glioblastoma undergoing adjuvant photon (n = 47) or proton (n = 19) radiochemotherapy with temozolomide after tumor resection underwent T1-weighted and arterial spin labeling MRI. Changes in volume and perfusion before and 3 to 6 months after were compared between therapies. A decrease in gray matter (GM) (−2.2%, P
ISSN:	0167-8140 1879-0887
DOI:	10.1016/j.radonc.2017.11.033