Hibiscus rosa sinensis mediate anxiolytic effect via modulation of ionotropic GABA-A receptors: possible mechanism of action
The current study was designed with the aim to investigate anti-anxiety potential of Hibiscus rosa sinensis roots and its possible mechanism of action. For this purpose hole board test, elevated plus maze test and light/dark exploration test were employed. The ethanol extract of plant was administer...
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| Veröffentlicht in: | Metabolic brain disease 2018-06, Vol.33 (3), p.823-827 |
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| creator | Begum, Zubia Younus, Ishrat |
| description | The current study was designed with the aim to investigate anti-anxiety potential of
Hibiscus rosa sinensis
roots and its possible mechanism of action. For this purpose hole board test, elevated plus maze test and light/dark exploration test were employed. The ethanol extract of plant was administered orally at two different doses i.e. 100 and 500 mg/kg for consecutive 14 days. The results of present investigation indicate that plant extract significantly (
p
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| doi_str_mv | 10.1007/s11011-018-0188-4 |
| format | Article |
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Hibiscus rosa sinensis
roots and its possible mechanism of action. For this purpose hole board test, elevated plus maze test and light/dark exploration test were employed. The ethanol extract of plant was administered orally at two different doses i.e. 100 and 500 mg/kg for consecutive 14 days. The results of present investigation indicate that plant extract significantly (
p
< 0.05) increased the number of head dips and rearings as compared to control on respective days of observation. The extract increased the time of permanence in open arms and the number of head dips in elevated plus maze. In light/dark test, our study indicate that
Hibiscus rosa sinensis
significantly (
p
< 0.05) increased the time spent in light compartment and number of entries as compared to control. In addition the anxiolytic effects of HRS at highest tested dose were blocked by flumazenil, a GABA-A receptor antagonist that indicate that
Hibiscus rosa sinensis
potentiated the GABAergic actions. The results propose that the ethanol extract of
Hibiscus rosa sinensis
has prospective anxiolytic effect in mice via inhibition of ionotropic GABA receptors, using different behavioral paradigms.</description><identifier>ISSN: 0885-7490</identifier><identifier>EISSN: 1573-7365</identifier><identifier>DOI: 10.1007/s11011-018-0188-4</identifier><identifier>PMID: 29372452</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animals ; Anti-Anxiety Agents - pharmacology ; Anxiety ; Anxiety - drug therapy ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Ethanol ; Flumazenil ; GABA-A Receptor Antagonists - pharmacology ; Hibiscus - drug effects ; Hibiscus rosa-sinensis ; Male ; Metabolic Diseases ; Mice ; Neurology ; Neurosciences ; Neurotransmitters ; Oncology ; Original Article ; Plant extracts ; Plant Extracts - pharmacology ; Plant Roots ; Receptors ; Receptors, GABA-A - drug effects ; Rosa - drug effects ; γ-Aminobutyric acid A receptors ; γ-Aminobutyric acid receptors</subject><ispartof>Metabolic brain disease, 2018-06, Vol.33 (3), p.823-827</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2018</rights><rights>Metabolic Brain Disease is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-9ecb941f09969bf8f378a2edb417da5a741ef0b10d0de7a4ee754f08a5c62e363</citedby><cites>FETCH-LOGICAL-c372t-9ecb941f09969bf8f378a2edb417da5a741ef0b10d0de7a4ee754f08a5c62e363</cites><orcidid>0000-0002-7032-6677</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11011-018-0188-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11011-018-0188-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27915,27916,41479,42548,51310</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29372452$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Begum, Zubia</creatorcontrib><creatorcontrib>Younus, Ishrat</creatorcontrib><title>Hibiscus rosa sinensis mediate anxiolytic effect via modulation of ionotropic GABA-A receptors: possible mechanism of action</title><title>Metabolic brain disease</title><addtitle>Metab Brain Dis</addtitle><addtitle>Metab Brain Dis</addtitle><description>The current study was designed with the aim to investigate anti-anxiety potential of
Hibiscus rosa sinensis
roots and its possible mechanism of action. For this purpose hole board test, elevated plus maze test and light/dark exploration test were employed. The ethanol extract of plant was administered orally at two different doses i.e. 100 and 500 mg/kg for consecutive 14 days. The results of present investigation indicate that plant extract significantly (
p
< 0.05) increased the number of head dips and rearings as compared to control on respective days of observation. The extract increased the time of permanence in open arms and the number of head dips in elevated plus maze. In light/dark test, our study indicate that
Hibiscus rosa sinensis
significantly (
p
< 0.05) increased the time spent in light compartment and number of entries as compared to control. In addition the anxiolytic effects of HRS at highest tested dose were blocked by flumazenil, a GABA-A receptor antagonist that indicate that
Hibiscus rosa sinensis
potentiated the GABAergic actions. The results propose that the ethanol extract of
Hibiscus rosa sinensis
has prospective anxiolytic effect in mice via inhibition of ionotropic GABA receptors, using different behavioral paradigms.</description><subject>Animals</subject><subject>Anti-Anxiety Agents - pharmacology</subject><subject>Anxiety</subject><subject>Anxiety - drug therapy</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Ethanol</subject><subject>Flumazenil</subject><subject>GABA-A Receptor Antagonists - pharmacology</subject><subject>Hibiscus - drug effects</subject><subject>Hibiscus rosa-sinensis</subject><subject>Male</subject><subject>Metabolic Diseases</subject><subject>Mice</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Neurotransmitters</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Plant extracts</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Roots</subject><subject>Receptors</subject><subject>Receptors, GABA-A - drug effects</subject><subject>Rosa - drug effects</subject><subject>γ-Aminobutyric acid A receptors</subject><subject>γ-Aminobutyric acid receptors</subject><issn>0885-7490</issn><issn>1573-7365</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kUGL1jAQhoMo7ufqD_AiAS9eqpM0aRpv3y66Kyx40XNJ04lmaZuaacUFf7wp3yoieBjmkOd9MzMvY88FvBYA5g0JAUJUINq92ko9YAehTV2ZutEP2QHaVldGWThjT4huAaDWwj5mZ9LWRiotD-zndewj-Y14TuQ4xRlnisQnHKJbkbv5R0zj3Ro9xxDQr_x7dHxKwza6NaaZp8BLS2tOS2GujhfH6sgzelzWlOktXxJR7Ecsjv6rmyNNu8T5XfyUPQpuJHx238_Z5_fvPl1eVzcfrz5cHm8qX8ZcK4u-t0oEsLaxfWhDbVonceiVMIPTziiBAXoBAwxonEI0WgVonfaNxLqpz9mrk--S07cNae2msjOOo5sxbdQJayUIKRso6Mt_0Nu05blMt1O10qYxbaHEifLlapQxdEuOk8t3nYBuj6Y7RdOVWPZqO1U0L-6dt75c94_idxYFkCeAytP8BfNfX__X9RclyZql</recordid><startdate>20180601</startdate><enddate>20180601</enddate><creator>Begum, Zubia</creator><creator>Younus, Ishrat</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7032-6677</orcidid></search><sort><creationdate>20180601</creationdate><title>Hibiscus rosa sinensis mediate anxiolytic effect via modulation of ionotropic GABA-A receptors: possible mechanism of action</title><author>Begum, Zubia ; Younus, Ishrat</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-9ecb941f09969bf8f378a2edb417da5a741ef0b10d0de7a4ee754f08a5c62e363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>Anti-Anxiety Agents - pharmacology</topic><topic>Anxiety</topic><topic>Anxiety - drug therapy</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Ethanol</topic><topic>Flumazenil</topic><topic>GABA-A Receptor Antagonists - pharmacology</topic><topic>Hibiscus - drug effects</topic><topic>Hibiscus rosa-sinensis</topic><topic>Male</topic><topic>Metabolic Diseases</topic><topic>Mice</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Neurotransmitters</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Plant extracts</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Roots</topic><topic>Receptors</topic><topic>Receptors, GABA-A - drug effects</topic><topic>Rosa - drug effects</topic><topic>γ-Aminobutyric acid A receptors</topic><topic>γ-Aminobutyric acid receptors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Begum, Zubia</creatorcontrib><creatorcontrib>Younus, Ishrat</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology Journals</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Metabolic brain disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Begum, Zubia</au><au>Younus, Ishrat</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hibiscus rosa sinensis mediate anxiolytic effect via modulation of ionotropic GABA-A receptors: possible mechanism of action</atitle><jtitle>Metabolic brain disease</jtitle><stitle>Metab Brain Dis</stitle><addtitle>Metab Brain Dis</addtitle><date>2018-06-01</date><risdate>2018</risdate><volume>33</volume><issue>3</issue><spage>823</spage><epage>827</epage><pages>823-827</pages><issn>0885-7490</issn><eissn>1573-7365</eissn><abstract>The current study was designed with the aim to investigate anti-anxiety potential of
Hibiscus rosa sinensis
roots and its possible mechanism of action. For this purpose hole board test, elevated plus maze test and light/dark exploration test were employed. The ethanol extract of plant was administered orally at two different doses i.e. 100 and 500 mg/kg for consecutive 14 days. The results of present investigation indicate that plant extract significantly (
p
< 0.05) increased the number of head dips and rearings as compared to control on respective days of observation. The extract increased the time of permanence in open arms and the number of head dips in elevated plus maze. In light/dark test, our study indicate that
Hibiscus rosa sinensis
significantly (
p
< 0.05) increased the time spent in light compartment and number of entries as compared to control. In addition the anxiolytic effects of HRS at highest tested dose were blocked by flumazenil, a GABA-A receptor antagonist that indicate that
Hibiscus rosa sinensis
potentiated the GABAergic actions. The results propose that the ethanol extract of
Hibiscus rosa sinensis
has prospective anxiolytic effect in mice via inhibition of ionotropic GABA receptors, using different behavioral paradigms.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>29372452</pmid><doi>10.1007/s11011-018-0188-4</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-7032-6677</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0885-7490 |
| ispartof | Metabolic brain disease, 2018-06, Vol.33 (3), p.823-827 |
| issn | 0885-7490 1573-7365 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animals Anti-Anxiety Agents - pharmacology Anxiety Anxiety - drug therapy Biochemistry Biomedical and Life Sciences Biomedicine Ethanol Flumazenil GABA-A Receptor Antagonists - pharmacology Hibiscus - drug effects Hibiscus rosa-sinensis Male Metabolic Diseases Mice Neurology Neurosciences Neurotransmitters Oncology Original Article Plant extracts Plant Extracts - pharmacology Plant Roots Receptors Receptors, GABA-A - drug effects Rosa - drug effects γ-Aminobutyric acid A receptors γ-Aminobutyric acid receptors |
| title | Hibiscus rosa sinensis mediate anxiolytic effect via modulation of ionotropic GABA-A receptors: possible mechanism of action |
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