Hibiscus rosa sinensis mediate anxiolytic effect via modulation of ionotropic GABA-A receptors: possible mechanism of action

The current study was designed with the aim to investigate anti-anxiety potential of Hibiscus rosa sinensis roots and its possible mechanism of action. For this purpose hole board test, elevated plus maze test and light/dark exploration test were employed. The ethanol extract of plant was administer...

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Veröffentlicht in:	Metabolic brain disease 2018-06, Vol.33 (3), p.823-827
Hauptverfasser:	Begum, Zubia, Younus, Ishrat
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Anxiety Agents - pharmacology Anxiety Anxiety - drug therapy Biochemistry Biomedical and Life Sciences Biomedicine Ethanol Flumazenil GABA-A Receptor Antagonists - pharmacology Hibiscus - drug effects Hibiscus rosa-sinensis Male Metabolic Diseases Mice Neurology Neurosciences Neurotransmitters Oncology Original Article Plant extracts Plant Extracts - pharmacology Plant Roots Receptors Receptors, GABA-A - drug effects Rosa - drug effects γ-Aminobutyric acid A receptors γ-Aminobutyric acid receptors
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Zusammenfassung:	The current study was designed with the aim to investigate anti-anxiety potential of Hibiscus rosa sinensis roots and its possible mechanism of action. For this purpose hole board test, elevated plus maze test and light/dark exploration test were employed. The ethanol extract of plant was administered orally at two different doses i.e. 100 and 500 mg/kg for consecutive 14 days. The results of present investigation indicate that plant extract significantly ( p
ISSN:	0885-7490 1573-7365
DOI:	10.1007/s11011-018-0188-4