IL-31: A new key player in dermatology and beyond

IL-31: A new key player in dermatology and beyond

IL-31 is a novel cytokine expressed in many human tissues and involved mainly in TH2-weighted inflammation. IL-31 signals through a receptor complex consisting of IL-31 receptor α and oncostatin M receptor β. The available data show that IL-31 is strongly linked with chronic pruritic skin disorders,...

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Veröffentlicht in:Journal of allergy and clinical immunology 2018-03, Vol.141 (3), p.858-866
Hauptverfasser: Bağci, Işın Sinem, Ruzicka, Thomas
Format: Artikel
Sprache:eng
Schlagworte:
Animal models
Asthma
atopic eczema
Atopy
Bone marrow
Cancer
Cytokines
Dermatitis
Dermatology
Eczema
IL-31
Immune response
Inflammation
interleukins
Kinases
Leukemia
Lymphocytes
Lymphocytes T
Musculoskeletal system
Oncostatin M
Prostate
pruritus
receptors
Skin diseases
Tissues
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Beschreibung
Zusammenfassung:IL-31 is a novel cytokine expressed in many human tissues and involved mainly in TH2-weighted inflammation. IL-31 signals through a receptor complex consisting of IL-31 receptor α and oncostatin M receptor β. The available data show that IL-31 is strongly linked with chronic pruritic skin disorders, such as atopic eczema, and represents a novel target for directed drug therapy. Regulation of immune responses and cellular differentiation and proliferation are recently elucidated effects of IL-31, suggesting a more complex and diverse area of effect for this novel cytokine. This review summarizes the current knowledge on IL-31 and its receptors and the involvement of IL-31 in diseases both in human subjects and mouse models.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2017.10.045