An (Old) New Strategy to Manage BPSD

Tune discusses the negative effect of cumulative anticholinergic exposure (or anticholinergic burden) on those living with dementia. In 125 patients living with dementia, a modest 20% reduction (achieved in 67% of subjects) in total anticholinergic burden resulted in significant improvements in stan...

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Veröffentlicht in:	The American journal of geriatric psychiatry 2018-03, Vol.26 (3), p.289-290
1. Verfasser:	Tune, Larry E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Behavioral psychology Behavioral Symptoms - chemically induced Behavioral Symptoms - etiology Behavioral Symptoms - physiopathology Behavioral Symptoms - prevention & control Cholinergic Antagonists - administration & dosage Cholinergic Antagonists - adverse effects Dementia Dementia - complications Dementia - drug therapy Humans Side effects
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Beschreibung
Zusammenfassung:	Tune discusses the negative effect of cumulative anticholinergic exposure (or anticholinergic burden) on those living with dementia. In 125 patients living with dementia, a modest 20% reduction (achieved in 67% of subjects) in total anticholinergic burden resulted in significant improvements in standard measures of behavioral and psychological symptom of dementia (BPSD). BPSD ratings on the NPI-NH, which assesses 12 domains of behavioral disturbance in commonly seen in dementia, showed a significant reduction in frequency x severity assessments.
ISSN:	1064-7481 1545-7214
DOI:	10.1016/j.jagp.2017.11.011