Efficient construction of bioactive trans-5A5B6C spirolactones via bicyclo[4.3.0] α-hydroxy ketones

Efficient construction of bioactive trans-5A5B6C spirolactones via bicyclo[4.3.0] α-hydroxy ketones

An efficient, convenient short synthetic procedure for the synthesis of the intricate 5A5B6C-ring fusion topologies of tricyclic spiranoid β-hydroxybutyrolactones through lactonization of the key intermediate trans-α-hydroxyindenones with malonates is described. All the compounds synthesized exhibit...

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Veröffentlicht in:Organic & biomolecular chemistry 2018, Vol.16 (7), p.1163-1166
Hauptverfasser: Zhu, Y J, Huo, J Q, Fan, Z J, Wu, Q F, X Li, Zhou, S, Xiong, L X, Kalinina, T, Glukhareva, T
Format: Artikel
Sprache:eng
Schlagworte:
Fungicides
Ketones
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Zusammenfassung:An efficient, convenient short synthetic procedure for the synthesis of the intricate 5A5B6C-ring fusion topologies of tricyclic spiranoid β-hydroxybutyrolactones through lactonization of the key intermediate trans-α-hydroxyindenones with malonates is described. All the compounds synthesized exhibited environmentally benign characteristics, moderate fungicidal, nematocidal, and anti-TMV activities.
ISSN:1477-0520
1477-0539
DOI:10.1039/c7ob02701j