Clinical characteristics and outcomes of cancer patients requiring intensive care unit admission: a prospective study
Purpose The study was aimed to describe the characteristics of cancer patients admitted to the oncological ICU and to identify clinical features associated with outcomes. Methods This is a prospective study (January 2014 to December 2015) of 522 cancer patients consecutively admitted to the oncologi...
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| Veröffentlicht in: | Journal of cancer research and clinical oncology 2018-04, Vol.144 (4), p.717-723 |
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| creator | Martos-Benítez, Frank Daniel Soto-García, Andrés Gutiérrez-Noyola, Anarelys |
| description | Purpose
The study was aimed to describe the characteristics of cancer patients admitted to the oncological ICU and to identify clinical features associated with outcomes.
Methods
This is a prospective study (January 2014 to December 2015) of 522 cancer patients consecutively admitted to the oncological ICU. Patients with a length of oncological ICU stay ≤ 1 day were excluded. Demographic and clinical variables were obtained at oncological ICU admission. The primary outcome of interest was hospital mortality. Logistic regression analysis was performed to identify independent risk factors for hospital mortality.
Results
The study cohort consisted of 492 (94.3%) patients with solid tumours and 30 patients (5.7%) with haematological malignancies. Advanced cancer was observed in 53.3%. Unplanned admission accounted for 25.3%. Hospital mortality rate was 13.0% (
n
= 68), and it was higher for patients with unplanned admission than those for electively admitted patients (35.6% vs. 5.4;
p
|
| doi_str_mv | 10.1007/s00432-018-2581-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1990856334</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1990856334</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-421758305f5ec125bae39ea7f84508b9cae912b7ca302715779aa53deaae77803</originalsourceid><addsrcrecordid>eNp1kc2KFDEURoMoTtvjA7iRgJvZlOan06m4k8ZRYcCNsw63U7c0Q3WqJjcR5u1N0aOI4CoknHw5Nx9jr6R4K4Ww70iInVadkH2nTC878YRt5HoitTZP2UZIKzuj5P6CvSC6E21vrHrOLpTTe-Vkv2H1MMUUA0w8_IAMoWCOVGIgDmngcy1hPiHxeeQBUsDMFygRUyGe8b7GHNN3HlPBRPEnNiYjrykWDsMpEsU5vefAlzzTgqGsCJU6PFyyZyNMhC8f1y27vf747fC5u_n66cvhw00XtFWl26km3GthRoNBKnME1A7Bjv3OiP7oAqCT6mgDaKGsNNY6AKMHBEBre6G37Oqc2wzuK1LxzSrgNEHCuZKXzone7LXeNfTNP-jdXHNqdivVCLdyWybPVGgjUcbRLzmeID94KfzaiT934lsnfu3ErxKvH5Pr8YTDnxu_S2iAOgO0rP-J-a-n_5v6C6BQmDc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1993349563</pqid></control><display><type>article</type><title>Clinical characteristics and outcomes of cancer patients requiring intensive care unit admission: a prospective study</title><source>MEDLINE</source><source>Springer journals</source><creator>Martos-Benítez, Frank Daniel ; Soto-García, Andrés ; Gutiérrez-Noyola, Anarelys</creator><creatorcontrib>Martos-Benítez, Frank Daniel ; Soto-García, Andrés ; Gutiérrez-Noyola, Anarelys</creatorcontrib><description><![CDATA[Purpose
The study was aimed to describe the characteristics of cancer patients admitted to the oncological ICU and to identify clinical features associated with outcomes.
Methods
This is a prospective study (January 2014 to December 2015) of 522 cancer patients consecutively admitted to the oncological ICU. Patients with a length of oncological ICU stay ≤ 1 day were excluded. Demographic and clinical variables were obtained at oncological ICU admission. The primary outcome of interest was hospital mortality. Logistic regression analysis was performed to identify independent risk factors for hospital mortality.
Results
The study cohort consisted of 492 (94.3%) patients with solid tumours and 30 patients (5.7%) with haematological malignancies. Advanced cancer was observed in 53.3%. Unplanned admission accounted for 25.3%. Hospital mortality rate was 13.0% (
n
= 68), and it was higher for patients with unplanned admission than those for electively admitted patients (35.6% vs. 5.4;
p
< 0.0001). Stage IV of cancer (OR 5.28; 95% CI 2.71–10.28;
p
< 0.0001), patients from the emergency department (OR 3.33; 95% CI 1.68–6.61;
p
= 0.001), unplanned admission (OR 7.99; 95% CI 4.45–14.33;
p
< 0.0001), non-malignancy-related admission (OR 5.80; 95% CI 3.26–10.32;
p
< 0.0001), sepsis (OR 4.81; 95% CI 2.28–10.16;
p
< 0.0001), chemotherapy-induced adverse event (OR 5.64; 95% CI 2.33–13.66;
p
< 0.0001), and invasive mechanical ventilation (OR 18.70; 95% CI 9.93–35.21;
p
< 0.0001) were independently associated with increased hospital mortality in multivariate logistic regression analysis.
Conclusions
ICU admission of cancer patients should be based on potential chance of recovering from the acute problem. Clinical predictor for mortality could support this purpose (UIN: researchregistry3484).]]></description><identifier>ISSN: 0171-5216</identifier><identifier>EISSN: 1432-1335</identifier><identifier>DOI: 10.1007/s00432-018-2581-0</identifier><identifier>PMID: 29362918</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aged ; Cancer ; Cancer Research ; Chemotherapy ; Cohort Studies ; Critical Care - methods ; Female ; Hematologic Neoplasms - mortality ; Hematologic Neoplasms - therapy ; Hematology ; Hospital Mortality ; Humans ; Intensive Care Units - statistics & numerical data ; Internal Medicine ; Invasiveness ; Male ; Malignancy ; Mechanical ventilation ; Medicine ; Medicine & Public Health ; Middle Aged ; Mortality ; Neoplasm Staging ; Neoplasms - mortality ; Neoplasms - pathology ; Neoplasms - therapy ; Oncology ; Original Article – Clinical Oncology ; Prospective Studies ; Regression analysis ; Risk factors ; Sepsis ; Solid tumors ; Treatment Outcome</subject><ispartof>Journal of cancer research and clinical oncology, 2018-04, Vol.144 (4), p.717-723</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2018</rights><rights>Journal of Cancer Research and Clinical Oncology is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-421758305f5ec125bae39ea7f84508b9cae912b7ca302715779aa53deaae77803</citedby><cites>FETCH-LOGICAL-c372t-421758305f5ec125bae39ea7f84508b9cae912b7ca302715779aa53deaae77803</cites><orcidid>0000-0001-7551-5373</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00432-018-2581-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00432-018-2581-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29362918$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Martos-Benítez, Frank Daniel</creatorcontrib><creatorcontrib>Soto-García, Andrés</creatorcontrib><creatorcontrib>Gutiérrez-Noyola, Anarelys</creatorcontrib><title>Clinical characteristics and outcomes of cancer patients requiring intensive care unit admission: a prospective study</title><title>Journal of cancer research and clinical oncology</title><addtitle>J Cancer Res Clin Oncol</addtitle><addtitle>J Cancer Res Clin Oncol</addtitle><description><![CDATA[Purpose
The study was aimed to describe the characteristics of cancer patients admitted to the oncological ICU and to identify clinical features associated with outcomes.
Methods
This is a prospective study (January 2014 to December 2015) of 522 cancer patients consecutively admitted to the oncological ICU. Patients with a length of oncological ICU stay ≤ 1 day were excluded. Demographic and clinical variables were obtained at oncological ICU admission. The primary outcome of interest was hospital mortality. Logistic regression analysis was performed to identify independent risk factors for hospital mortality.
Results
The study cohort consisted of 492 (94.3%) patients with solid tumours and 30 patients (5.7%) with haematological malignancies. Advanced cancer was observed in 53.3%. Unplanned admission accounted for 25.3%. Hospital mortality rate was 13.0% (
n
= 68), and it was higher for patients with unplanned admission than those for electively admitted patients (35.6% vs. 5.4;
p
< 0.0001). Stage IV of cancer (OR 5.28; 95% CI 2.71–10.28;
p
< 0.0001), patients from the emergency department (OR 3.33; 95% CI 1.68–6.61;
p
= 0.001), unplanned admission (OR 7.99; 95% CI 4.45–14.33;
p
< 0.0001), non-malignancy-related admission (OR 5.80; 95% CI 3.26–10.32;
p
< 0.0001), sepsis (OR 4.81; 95% CI 2.28–10.16;
p
< 0.0001), chemotherapy-induced adverse event (OR 5.64; 95% CI 2.33–13.66;
p
< 0.0001), and invasive mechanical ventilation (OR 18.70; 95% CI 9.93–35.21;
p
< 0.0001) were independently associated with increased hospital mortality in multivariate logistic regression analysis.
Conclusions
ICU admission of cancer patients should be based on potential chance of recovering from the acute problem. Clinical predictor for mortality could support this purpose (UIN: researchregistry3484).]]></description><subject>Aged</subject><subject>Cancer</subject><subject>Cancer Research</subject><subject>Chemotherapy</subject><subject>Cohort Studies</subject><subject>Critical Care - methods</subject><subject>Female</subject><subject>Hematologic Neoplasms - mortality</subject><subject>Hematologic Neoplasms - therapy</subject><subject>Hematology</subject><subject>Hospital Mortality</subject><subject>Humans</subject><subject>Intensive Care Units - statistics & numerical data</subject><subject>Internal Medicine</subject><subject>Invasiveness</subject><subject>Male</subject><subject>Malignancy</subject><subject>Mechanical ventilation</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Neoplasm Staging</subject><subject>Neoplasms - mortality</subject><subject>Neoplasms - pathology</subject><subject>Neoplasms - therapy</subject><subject>Oncology</subject><subject>Original Article – Clinical Oncology</subject><subject>Prospective Studies</subject><subject>Regression analysis</subject><subject>Risk factors</subject><subject>Sepsis</subject><subject>Solid tumors</subject><subject>Treatment Outcome</subject><issn>0171-5216</issn><issn>1432-1335</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kc2KFDEURoMoTtvjA7iRgJvZlOan06m4k8ZRYcCNsw63U7c0Q3WqJjcR5u1N0aOI4CoknHw5Nx9jr6R4K4Ww70iInVadkH2nTC878YRt5HoitTZP2UZIKzuj5P6CvSC6E21vrHrOLpTTe-Vkv2H1MMUUA0w8_IAMoWCOVGIgDmngcy1hPiHxeeQBUsDMFygRUyGe8b7GHNN3HlPBRPEnNiYjrykWDsMpEsU5vefAlzzTgqGsCJU6PFyyZyNMhC8f1y27vf747fC5u_n66cvhw00XtFWl26km3GthRoNBKnME1A7Bjv3OiP7oAqCT6mgDaKGsNNY6AKMHBEBre6G37Oqc2wzuK1LxzSrgNEHCuZKXzone7LXeNfTNP-jdXHNqdivVCLdyWybPVGgjUcbRLzmeID94KfzaiT934lsnfu3ErxKvH5Pr8YTDnxu_S2iAOgO0rP-J-a-n_5v6C6BQmDc</recordid><startdate>20180401</startdate><enddate>20180401</enddate><creator>Martos-Benítez, Frank Daniel</creator><creator>Soto-García, Andrés</creator><creator>Gutiérrez-Noyola, Anarelys</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7551-5373</orcidid></search><sort><creationdate>20180401</creationdate><title>Clinical characteristics and outcomes of cancer patients requiring intensive care unit admission: a prospective study</title><author>Martos-Benítez, Frank Daniel ; Soto-García, Andrés ; Gutiérrez-Noyola, Anarelys</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-421758305f5ec125bae39ea7f84508b9cae912b7ca302715779aa53deaae77803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aged</topic><topic>Cancer</topic><topic>Cancer Research</topic><topic>Chemotherapy</topic><topic>Cohort Studies</topic><topic>Critical Care - methods</topic><topic>Female</topic><topic>Hematologic Neoplasms - mortality</topic><topic>Hematologic Neoplasms - therapy</topic><topic>Hematology</topic><topic>Hospital Mortality</topic><topic>Humans</topic><topic>Intensive Care Units - statistics & numerical data</topic><topic>Internal Medicine</topic><topic>Invasiveness</topic><topic>Male</topic><topic>Malignancy</topic><topic>Mechanical ventilation</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Neoplasm Staging</topic><topic>Neoplasms - mortality</topic><topic>Neoplasms - pathology</topic><topic>Neoplasms - therapy</topic><topic>Oncology</topic><topic>Original Article – Clinical Oncology</topic><topic>Prospective Studies</topic><topic>Regression analysis</topic><topic>Risk factors</topic><topic>Sepsis</topic><topic>Solid tumors</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Martos-Benítez, Frank Daniel</creatorcontrib><creatorcontrib>Soto-García, Andrés</creatorcontrib><creatorcontrib>Gutiérrez-Noyola, Anarelys</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database (ProQuest)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Research Library (ProQuest Database)</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cancer research and clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Martos-Benítez, Frank Daniel</au><au>Soto-García, Andrés</au><au>Gutiérrez-Noyola, Anarelys</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical characteristics and outcomes of cancer patients requiring intensive care unit admission: a prospective study</atitle><jtitle>Journal of cancer research and clinical oncology</jtitle><stitle>J Cancer Res Clin Oncol</stitle><addtitle>J Cancer Res Clin Oncol</addtitle><date>2018-04-01</date><risdate>2018</risdate><volume>144</volume><issue>4</issue><spage>717</spage><epage>723</epage><pages>717-723</pages><issn>0171-5216</issn><eissn>1432-1335</eissn><abstract><![CDATA[Purpose
The study was aimed to describe the characteristics of cancer patients admitted to the oncological ICU and to identify clinical features associated with outcomes.
Methods
This is a prospective study (January 2014 to December 2015) of 522 cancer patients consecutively admitted to the oncological ICU. Patients with a length of oncological ICU stay ≤ 1 day were excluded. Demographic and clinical variables were obtained at oncological ICU admission. The primary outcome of interest was hospital mortality. Logistic regression analysis was performed to identify independent risk factors for hospital mortality.
Results
The study cohort consisted of 492 (94.3%) patients with solid tumours and 30 patients (5.7%) with haematological malignancies. Advanced cancer was observed in 53.3%. Unplanned admission accounted for 25.3%. Hospital mortality rate was 13.0% (
n
= 68), and it was higher for patients with unplanned admission than those for electively admitted patients (35.6% vs. 5.4;
p
< 0.0001). Stage IV of cancer (OR 5.28; 95% CI 2.71–10.28;
p
< 0.0001), patients from the emergency department (OR 3.33; 95% CI 1.68–6.61;
p
= 0.001), unplanned admission (OR 7.99; 95% CI 4.45–14.33;
p
< 0.0001), non-malignancy-related admission (OR 5.80; 95% CI 3.26–10.32;
p
< 0.0001), sepsis (OR 4.81; 95% CI 2.28–10.16;
p
< 0.0001), chemotherapy-induced adverse event (OR 5.64; 95% CI 2.33–13.66;
p
< 0.0001), and invasive mechanical ventilation (OR 18.70; 95% CI 9.93–35.21;
p
< 0.0001) were independently associated with increased hospital mortality in multivariate logistic regression analysis.
Conclusions
ICU admission of cancer patients should be based on potential chance of recovering from the acute problem. Clinical predictor for mortality could support this purpose (UIN: researchregistry3484).]]></abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>29362918</pmid><doi>10.1007/s00432-018-2581-0</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-7551-5373</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0171-5216 |
| ispartof | Journal of cancer research and clinical oncology, 2018-04, Vol.144 (4), p.717-723 |
| issn | 0171-5216 1432-1335 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1990856334 |
| source | MEDLINE; Springer journals |
| subjects | Aged Cancer Cancer Research Chemotherapy Cohort Studies Critical Care - methods Female Hematologic Neoplasms - mortality Hematologic Neoplasms - therapy Hematology Hospital Mortality Humans Intensive Care Units - statistics & numerical data Internal Medicine Invasiveness Male Malignancy Mechanical ventilation Medicine Medicine & Public Health Middle Aged Mortality Neoplasm Staging Neoplasms - mortality Neoplasms - pathology Neoplasms - therapy Oncology Original Article – Clinical Oncology Prospective Studies Regression analysis Risk factors Sepsis Solid tumors Treatment Outcome |
| title | Clinical characteristics and outcomes of cancer patients requiring intensive care unit admission: a prospective study |
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