Protein Adsorption is Dependent on Substrate Polymer Polymorphs

Protein Adsorption is Dependent on Substrate Polymer Polymorphs

Adhesion force, quartz crystal microbalance (QCM), and attenuated total reflection infrared (ATR-IR) measurements revealed that native proteins weakly adsorbed onto poly(lactide) (PLA) stereocomplexes with 31 helical (β-form) crystals when compared with poly(L-lactide) (PLLA) homogeneous crystals wi...

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Veröffentlicht in:Chemistry letters 2007-10, Vol.36 (10), p.1238-1239
Hauptverfasser: Matsuno, Hisao, Nagasaka, Yuya, Kurita, Kimio, Serizawa, Takeshi
Format: Artikel
Sprache:eng
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Zusammenfassung:Adhesion force, quartz crystal microbalance (QCM), and attenuated total reflection infrared (ATR-IR) measurements revealed that native proteins weakly adsorbed onto poly(lactide) (PLA) stereocomplexes with 31 helical (β-form) crystals when compared with poly(L-lactide) (PLLA) homogeneous crystals with 103 helical (α-form) crystals. These observations suggest that substrate polymer polymorphs can be significant factors that determine protein-adsorptive properties.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.2007.1238