Synthesis and antibacterial activity of the sulfonamide based schiff base and its transition metal (II) complexes

Synthesis and antibacterial activity of the sulfonamide based schiff base and its transition metal (II) complexes

A Schiff base 3 has been synthesized by equimolar reaction (condensation) of sulfonamide i.e. sulfamethoxypyridazine 1 and substituted aromatic aldehyde i.e. 2-Hydroxy-1-Napthalene aldehyde 2. The synthesized Schiff base 3 and its Metal (II) complexes were characterized by its physical, analytical (...

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Veröffentlicht in:Pakistan journal of pharmaceutical sciences 2018-01, Vol.31 (1), p.103-111
Hauptverfasser: Khan, Mehak Nawaz, Khan, Abdul Majeed, Ullah, Hamid, Hussain, Sajjad, Khattak, Azim Khan
Format: Artikel
Sprache:eng
Schlagworte:
Coordination compounds
Health aspects
Pharmaceutical research
Properties
Schiff bases
Sulfonamides
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Zusammenfassung:A Schiff base 3 has been synthesized by equimolar reaction (condensation) of sulfonamide i.e. sulfamethoxypyridazine 1 and substituted aromatic aldehyde i.e. 2-Hydroxy-1-Napthalene aldehyde 2. The synthesized Schiff base 3 and its Metal (II) complexes were characterized by its physical, analytical (CHN analysis) and spectral (UV & IR) analysis. The Staphylococcus aureus and Escherichia coli bacterial strains were used for antibacterial activity of Sulfamethoxypyridazine 1, its Schiff base 3 and its transition metal (II) complexes 4-8. All of them showed varied levels of activity.
ISSN:1011-601X