mTECs Aire on the side of caution
The transcription factor Aire restrains the transcriptional duration and amplitude of tissue-specific self-antigens by opposing the activity of the chromatin remodeler Brg1—a process required for immune tolerance.
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| Veröffentlicht in: | Nature immunology 2018-02, Vol.19 (2), p.100-101 |
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| container_end_page | 101 |
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| container_issue | 2 |
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| container_title | Nature immunology |
| container_volume | 19 |
| creator | Bortnick, Alexandra Murre, Cornelis |
| description | The transcription factor Aire restrains the transcriptional duration and amplitude of tissue-specific self-antigens by opposing the activity of the chromatin remodeler Brg1—a process required for immune tolerance. |
| doi_str_mv | 10.1038/s41590-017-0033-7 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1529-2908 |
| ispartof | Nature immunology, 2018-02, Vol.19 (2), p.100-101 |
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| language | eng |
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| source | MEDLINE; Nature; SpringerLink Journals - AutoHoldings |
| subjects | Antigens Apoptosis Autoantigens B cells Biomedical and Life Sciences Biomedicine BRG1 protein Cell Differentiation Chromatin Death DNA binding proteins Gene Expression Regulation Genes Immune Tolerance Immunological tolerance Immunology Infectious Diseases Liver News & Views news-and-views T cells Universities and colleges |
| title | mTECs Aire on the side of caution |
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