mTECs Aire on the side of caution

mTECs Aire on the side of caution

The transcription factor Aire restrains the transcriptional duration and amplitude of tissue-specific self-antigens by opposing the activity of the chromatin remodeler Brg1—a process required for immune tolerance.

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Bibliographische Detailangaben
Veröffentlicht in:Nature immunology 2018-02, Vol.19 (2), p.100-101
Hauptverfasser: Bortnick, Alexandra, Murre, Cornelis
Format: Artikel
Sprache:eng
Schlagworte:
Antigens
Apoptosis
Autoantigens
B cells
Biomedical and Life Sciences
Biomedicine
BRG1 protein
Cell Differentiation
Chromatin
Death
DNA binding proteins
Gene Expression Regulation
Genes
Immune Tolerance
Immunological tolerance
Immunology
Infectious Diseases
Liver
News & Views
news-and-views
T cells
Universities and colleges
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Beschreibung
Zusammenfassung:The transcription factor Aire restrains the transcriptional duration and amplitude of tissue-specific self-antigens by opposing the activity of the chromatin remodeler Brg1—a process required for immune tolerance.
ISSN:1529-2908
1529-2916
DOI:10.1038/s41590-017-0033-7