Adjunctive Glucocorticoid Therapy in Patients with Septic Shock
Whether hydrocortisone reduces mortality among patients with septic shock is unclear. Patients with septic shock undergoing mechanical ventilation were assigned to receive an infusion of hydrocortisone or placebo. Hydrocortisone did not result in lower 90-day mortality.
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| Veröffentlicht in: | The New England journal of medicine 2018-03, Vol.378 (9), p.797-808 |
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| container_title | The New England journal of medicine |
| container_volume | 378 |
| creator | Venkatesh, Balasubramanian Finfer, Simon Cohen, Jeremy Rajbhandari, Dorrilyn Arabi, Yaseen Bellomo, Rinaldo Billot, Laurent Correa, Maryam Glass, Parisa Harward, Meg Joyce, Christopher Li, Qiang McArthur, Colin Perner, Anders Rhodes, Andrew Thompson, Kelly Webb, Steve Myburgh, John |
| description | Whether hydrocortisone reduces mortality among patients with septic shock is unclear. Patients with septic shock undergoing mechanical ventilation were assigned to receive an infusion of hydrocortisone or placebo. Hydrocortisone did not result in lower 90-day mortality. |
| doi_str_mv | 10.1056/NEJMoa1705835 |
| format | Article |
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Patients with septic shock undergoing mechanical ventilation were assigned to receive an infusion of hydrocortisone or placebo. 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All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-d9d03f75b47b30bf5c979ab161f4ef4967ce095b1f8388e510b5284933d021753</citedby><cites>FETCH-LOGICAL-c390t-d9d03f75b47b30bf5c979ab161f4ef4967ce095b1f8388e510b5284933d021753</cites><orcidid>0000-0002-4975-9793</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMoa1705835$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJMoa1705835$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29347874$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Venkatesh, Balasubramanian</creatorcontrib><creatorcontrib>Finfer, Simon</creatorcontrib><creatorcontrib>Cohen, Jeremy</creatorcontrib><creatorcontrib>Rajbhandari, Dorrilyn</creatorcontrib><creatorcontrib>Arabi, Yaseen</creatorcontrib><creatorcontrib>Bellomo, Rinaldo</creatorcontrib><creatorcontrib>Billot, Laurent</creatorcontrib><creatorcontrib>Correa, Maryam</creatorcontrib><creatorcontrib>Glass, Parisa</creatorcontrib><creatorcontrib>Harward, Meg</creatorcontrib><creatorcontrib>Joyce, Christopher</creatorcontrib><creatorcontrib>Li, Qiang</creatorcontrib><creatorcontrib>McArthur, Colin</creatorcontrib><creatorcontrib>Perner, Anders</creatorcontrib><creatorcontrib>Rhodes, Andrew</creatorcontrib><creatorcontrib>Thompson, Kelly</creatorcontrib><creatorcontrib>Webb, Steve</creatorcontrib><creatorcontrib>Myburgh, John</creatorcontrib><creatorcontrib>ADRENAL Trial Investigators and the Australian–New Zealand Intensive Care Society Clinical Trials Group</creatorcontrib><title>Adjunctive Glucocorticoid Therapy in Patients with Septic Shock</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>Whether hydrocortisone reduces mortality among patients with septic shock is unclear. Patients with septic shock undergoing mechanical ventilation were assigned to receive an infusion of hydrocortisone or placebo. Hydrocortisone did not result in lower 90-day mortality.</description><subject>Aged</subject><subject>Anti-Inflammatory Agents - adverse effects</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>APACHE</subject><subject>Bacteremia</subject><subject>Bacteremia - etiology</subject><subject>Blood transfusion</subject><subject>Chemotherapy, Adjuvant</subject><subject>Clinical medicine</subject><subject>Design</subject><subject>Double-Blind Method</subject><subject>Drug dosages</subject><subject>Female</subject><subject>Fungemia</subject><subject>Fungemia - etiology</subject><subject>Glucocorticoids</subject><subject>Health care</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hydrocortisone</subject><subject>Hydrocortisone - adverse effects</subject><subject>Hydrocortisone - therapeutic use</subject><subject>Infusions, Intravenous</subject><subject>Intensive care</subject><subject>Male</subject><subject>Mechanical ventilation</subject><subject>Medical research</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Pharmacy</subject><subject>Preventive medicine</subject><subject>Recurrence</subject><subject>Renal Replacement Therapy</subject><subject>Respiration, Artificial</subject><subject>Sepsis</subject><subject>Septic shock</subject><subject>Shock, Septic - 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| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 2018-03, Vol.378 (9), p.797-808 |
| issn | 0028-4793 1533-4406 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; New England Journal of Medicine Current |
| subjects | Aged Anti-Inflammatory Agents - adverse effects Anti-Inflammatory Agents - therapeutic use APACHE Bacteremia Bacteremia - etiology Blood transfusion Chemotherapy, Adjuvant Clinical medicine Design Double-Blind Method Drug dosages Female Fungemia Fungemia - etiology Glucocorticoids Health care Hospitals Humans Hydrocortisone Hydrocortisone - adverse effects Hydrocortisone - therapeutic use Infusions, Intravenous Intensive care Male Mechanical ventilation Medical research Middle Aged Mortality Pharmacy Preventive medicine Recurrence Renal Replacement Therapy Respiration, Artificial Sepsis Septic shock Shock, Septic - complications Shock, Septic - drug therapy Shock, Septic - mortality Shock, Septic - therapy Statistical analysis Survival Rate Treatment Outcome Ventilators |
| title | Adjunctive Glucocorticoid Therapy in Patients with Septic Shock |
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