Adjunctive Glucocorticoid Therapy in Patients with Septic Shock

Whether hydrocortisone reduces mortality among patients with septic shock is unclear. Patients with septic shock undergoing mechanical ventilation were assigned to receive an infusion of hydrocortisone or placebo. Hydrocortisone did not result in lower 90-day mortality.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2018-03, Vol.378 (9), p.797-808
Hauptverfasser:	Venkatesh, Balasubramanian, Finfer, Simon, Cohen, Jeremy, Rajbhandari, Dorrilyn, Arabi, Yaseen, Bellomo, Rinaldo, Billot, Laurent, Correa, Maryam, Glass, Parisa, Harward, Meg, Joyce, Christopher, Li, Qiang, McArthur, Colin, Perner, Anders, Rhodes, Andrew, Thompson, Kelly, Webb, Steve, Myburgh, John
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Anti-Inflammatory Agents - adverse effects Anti-Inflammatory Agents - therapeutic use APACHE Bacteremia Bacteremia - etiology Blood transfusion Chemotherapy, Adjuvant Clinical medicine Design Double-Blind Method Drug dosages Female Fungemia Fungemia - etiology Glucocorticoids Health care Hospitals Humans Hydrocortisone Hydrocortisone - adverse effects Hydrocortisone - therapeutic use Infusions, Intravenous Intensive care Male Mechanical ventilation Medical research Middle Aged Mortality Pharmacy Preventive medicine Recurrence Renal Replacement Therapy Respiration, Artificial Sepsis Septic shock Shock, Septic - complications Shock, Septic - drug therapy Shock, Septic - mortality Shock, Septic - therapy Statistical analysis Survival Rate Treatment Outcome Ventilators
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Whether hydrocortisone reduces mortality among patients with septic shock is unclear. Patients with septic shock undergoing mechanical ventilation were assigned to receive an infusion of hydrocortisone or placebo. Hydrocortisone did not result in lower 90-day mortality.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa1705835