Solid dispersions to enhance the delivery of a potential drug candidate LPSF/FZ4 for the treatment of schistosomiasis

Drug candidate LPSF/FZ4 with promising schistosomicidal properties in vitro was previously synthesized. However, LPSF/FZ4 has limited aqueous solubility (

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Veröffentlicht in:European journal of pharmaceutical sciences 2018-03, Vol.115, p.270-285
Hauptverfasser: Schver, Giovanna C.R.M., Sun, Dajun D., Costa, Salvana P.M., Silva, Keyla E.R., Oliveira, Jamerson F., Rolim, Larissa Araujo, de Azevedo Albuquerque, Mônica Camelo Pessôa, de Lima Aires, André, Lima, Maria do Carmo A., Pitta, Ivan R., Lee, Ping I., Rolim-Neto, Pedro J.
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Sprache:eng
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Zusammenfassung:Drug candidate LPSF/FZ4 with promising schistosomicidal properties in vitro was previously synthesized. However, LPSF/FZ4 has limited aqueous solubility (
ISSN:0928-0987
1879-0720
DOI:10.1016/j.ejps.2018.01.014