Synthetic Strategy toward the Pentacyclic Core of Melodinus Alkaloids

Synthetic Strategy toward the Pentacyclic Core of Melodinus Alkaloids

The three-component Povarov reaction is efficiently utilized for construction of the pentacyclic framework of complex Melodinus alkaloids, which is amenable to expansion to other complex natural products. The key steps were Povarov reaction, one-pot reductive cyclization, and ring-closing metathesis...

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Veröffentlicht in:Journal of organic chemistry 2018-02, Vol.83 (4), p.2244-2249
Hauptverfasser: Goli, Navya, Kallepu, Shivakrishna, Mainkar, Prathama S, Lakshmi, Jerripothula K, Chegondi, Rambabu, Chandrasekhar, Srivari
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container_end_page 2249
container_issue 4
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container_title Journal of organic chemistry
container_volume 83
creator Goli, Navya
Kallepu, Shivakrishna
Mainkar, Prathama S
Lakshmi, Jerripothula K
Chegondi, Rambabu
Chandrasekhar, Srivari
description The three-component Povarov reaction is efficiently utilized for construction of the pentacyclic framework of complex Melodinus alkaloids, which is amenable to expansion to other complex natural products. The key steps were Povarov reaction, one-pot reductive cyclization, and ring-closing metathesis (RCM) reaction.
doi_str_mv 10.1021/acs.joc.7b03138
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title Synthetic Strategy toward the Pentacyclic Core of Melodinus Alkaloids
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