Synthetic Strategy toward the Pentacyclic Core of Melodinus Alkaloids

Synthetic Strategy toward the Pentacyclic Core of Melodinus Alkaloids

The three-component Povarov reaction is efficiently utilized for construction of the pentacyclic framework of complex Melodinus alkaloids, which is amenable to expansion to other complex natural products. The key steps were Povarov reaction, one-pot reductive cyclization, and ring-closing metathesis...

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Veröffentlicht in:Journal of organic chemistry 2018-02, Vol.83 (4), p.2244-2249
Hauptverfasser: Goli, Navya, Kallepu, Shivakrishna, Mainkar, Prathama S, Lakshmi, Jerripothula K, Chegondi, Rambabu, Chandrasekhar, Srivari
Format: Artikel
Sprache:eng
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Zusammenfassung:The three-component Povarov reaction is efficiently utilized for construction of the pentacyclic framework of complex Melodinus alkaloids, which is amenable to expansion to other complex natural products. The key steps were Povarov reaction, one-pot reductive cyclization, and ring-closing metathesis (RCM) reaction.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.7b03138