The Functional Immune Response of Patients on Extracorporeal Life Support

The Functional Immune Response of Patients on Extracorporeal Life Support

Extracorporeal life support (ECLS) is a widely used lifesaving technology. Whether ECLS results in immune dysregulation is unclear. This study’s aim was to examine whether ECLS affected innate immune response. All patients placed on ECLS were eligible. Blood was obtained before, during, and after EC...

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Veröffentlicht in:ASAIO journal (1992) 2019-01, Vol.65 (1), p.77-83
Hauptverfasser: Beshish, Asaad G, Bradley, Jeffrey D, McDonough, Kelli L, Halligan, Nadine L N, McHugh, Walker M, Sturza, Julie, Hall, Mark W, Cornell, Timothy T, Dahmer, Mary K
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Child, Preschool
Cohort Studies
Extracorporeal Membrane Oxygenation
Female
Humans
Immunity, Innate - immunology
Infant
Infant, Newborn
Male
Middle Aged
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Zusammenfassung:Extracorporeal life support (ECLS) is a widely used lifesaving technology. Whether ECLS results in immune dysregulation is unclear. This study’s aim was to examine whether ECLS affected innate immune response. All patients placed on ECLS were eligible. Blood was obtained before, during, and after ECLS. Function of the innate immune system was measured by ex vivo lipopolysaccharide (LPS)-induced tumor necrosis factor-α (TNF-α) and plasma cytokine levels (interleukin [IL]-6, IL-8, IL-10, and TNF-α). Immunoparalysis was defined as ex vivo TNF-α levels less than 200 pg/ml. Nineteen patients were enrolled with twelve
ISSN:1058-2916
1538-943X
DOI:10.1097/MAT.0000000000000748