Reply: Interaction Between Longitudinal, Circumferential, and Radial Deformations and Their Contributions to Ejection Fraction

[...]MCF can easily be extracted in our mathematical model, and we encourage such a theoretical investigation, which we believe would provide valuable insights regarding the relation between MCF versus strains, ejection fraction (EF), wall thickness, and cavity volume.Active circumferential fiber shortening directly reduces the cavity diameter and indirectly reduces it further by generating another component of radial stretching forces that contribute to the wall thickening.[...]these would stretch (due to increased pressure + Poisson’s ratio effect), resulting in an outward motion of the epicardium.