Evaluation of sex hormones and sperm parameters in male epileptic patients

Objectives The aim of this study was to investigate the effect of carbamazepine (CBZ) and sodium valproate (VPA) monotherapy on sexual functions, sex hormones, and semen analysis and quality in male patients with epilepsy. Methods A total of 59 male patients with epilepsy, of which 30 were on VPA monotherapy and 29 were on CBZ monotherapy, were included in the study between January 2015 and March 2016. A control group was established with 30 healthy males. Luteinizing hormone (LH), follicle‐stimulating hormone (FSH), prolactin (PRL), free testosterone (fT), estradiol (E2), sex hormone‐binding globulin (SHBG) levels and bioactive testosterone (BAT)/bioactive estradiol (BAE), and BAT/LH ratio were studied in groups. All groups received semen analysis and International Index of Erectile Function Scale (IIEF‐5) test for erectile dysfunction. Results E2 and DHEAS levels were higher in VPA and CBZ groups compared to control group (P .05). BAT/BAE ratios were low both in VPA and CBZ groups (P