Diabetic nephropathy: Is there a role for oxidative stress?

Oxidative stress has been implicated in the pathophysiology of diabetic nephropathy. Studies in experimental animal models of diabetes strongly implicate oxidant species as a major determinant in the pathophysiology of diabetic kidney disease. The translation, in the clinical setting, of these concepts have been quite disappointing, and new theories have challenged the concepts that oxidative stress per se plays a role in the pathophysiology of diabetic kidney disease. The concept of mitochondrial hormesis has been introduced to explain this apparent disconnect. Hormesis is intended as any cellular process that exhibits a biphasic response to exposure to increasing amounts of a substance or condition: specifically, in diabetic kidney disease, oxidant species may represent, at determined concentration, an essential and potentially protective factor. It could be postulated that excessive production or inhibition of oxidant species formation might result in an adverse phenotype. This review discusses the evidence underlying these two apparent contradicting concepts, with the aim to propose and speculate on potential mechanisms underlying the role of oxidant species in the pathophysiology of diabetic nephropathy and possibly open future more efficient therapies to be tested in the clinical settings. Mitochondrial hormesis could represent an important concept that could allow us to dissect the hazardous vs beneficial role of reactive oxygen species levels in the pathophysiology of diabetic nephropathy. [Display omitted] •Experimental models suggest a role for oxidative stress in diabetic nephropathy.•Clinical trials with antioxidant therapy have not delivered convincing results.•Targeting oxidative stress in diseases should modulate reactive oxygen species formation.•Targeting oxidative stress may require different strategies in different phases of diseases.