Corneal nerve regeneration after herpes simplex keratitis: A longitudinal in vivo confocal microscopy study
To evaluate the long-term alterations of corneal nerves in patients with herpes simplex virus (HSV) keratitis using in vivo confocal microscopy (IVCM). Prospective, longitudinal, cross sectional. This study included 16 patients with a history of HSV keratitis and 15 age-matched normal controls. Slit...
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Veröffentlicht in: | The ocular surface 2018-04, Vol.16 (2), p.218-225 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | To evaluate the long-term alterations of corneal nerves in patients with herpes simplex virus (HSV) keratitis using in vivo confocal microscopy (IVCM).
Prospective, longitudinal, cross sectional.
This study included 16 patients with a history of HSV keratitis and 15 age-matched normal controls. Slit-scanning IVCM was performed in all subjects at baseline and then after a mean follow-up of 37.3 ± 1.7 months in the patient group. Corneal subbasal nerve density and corneal sensation were compared between groups at baseline and follow-up.
At baseline, the mean subbasal nerve density was significantly lower in both affected eyes (1.4 ± 0.6 mm/mm2) and contralateral unaffected eyes (6.4 ± 0.7 mm/mm2) compared with the controls (14.1 ± 1.6 mm/mm2; all P |
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ISSN: | 1542-0124 1937-5913 |
DOI: | 10.1016/j.jtos.2017.12.001 |