Prognostic Value of Free Triiodothyronine Level in Patients With Hypertrophic Obstructive Cardiomyopathy
Context Thyroid hormone acts as a fundamental regulator in cardiovascular homeostasis in pathophysiological conditions. Objective This study aims to determine whether thyroid hormone could be an independent predictor of adverse events in patients with hypertrophic obstructive cardiomyopathy (HOCM)....
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| Veröffentlicht in: | The journal of clinical endocrinology and metabolism 2018-03, Vol.103 (3), p.1198-1205 |
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| creator | Zhang, Kuo Meng, Xiangbin Wang, Wenyao Zheng, Jilin An, Shimin Wang, Siyuan Qi, Yu Gao, Chuanyu Tang, Yi-Da |
| description | Context Thyroid hormone acts as a fundamental regulator in cardiovascular homeostasis in pathophysiological conditions. Objective This study aims to determine whether thyroid hormone could be an independent predictor of adverse events in patients with hypertrophic obstructive cardiomyopathy (HOCM). Design, Patients, and Outcome Measures The original cohort consisted of 965 consecutive patients with HOCM who were admitted to Fuwai Hospital from October 2009 to December 2014, and 756 patients completed thyroid function evaluations. Patients were divided into three groups according to free triiodothyronine (FT3) levels: tertile 1 ( |
| doi_str_mv | 10.1210/jc.2017-02386 |
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Objective This study aims to determine whether thyroid hormone could be an independent predictor of adverse events in patients with hypertrophic obstructive cardiomyopathy (HOCM). Design, Patients, and Outcome Measures The original cohort consisted of 965 consecutive patients with HOCM who were admitted to Fuwai Hospital from October 2009 to December 2014, and 756 patients completed thyroid function evaluations. Patients were divided into three groups according to free triiodothyronine (FT3) levels: tertile 1 (<2.81 pg/mL, n = 247), tertile 2 (2.81 to 3.11 pg/mL, n = 250), tertile 3 (3.12 to 4.09 pg/mL, n = 259). Results In correlation analysis, FT3 showed significantly positive correlation with left ventricular ejection fraction (r = 0.109, P = 0.003). After a median follow-up of 44 months, a total of 45 (6.0%) endpoints (all-cause mortality or cardiac transplantation) occurred with rates of 13.4%, 3.6%, and 1.2% in tertiles 1, 2, and 3, respectively. Univariate Cox analysis established FT3 as a predictor of endpoint [hazard ratio (HR), 0.111; 95% confidence interval (CI), 0.065, 0.189; P < 0.001]. After adjustment for traditional risk factors, the prognostic value of FT3 level was still significant (HR, 0.216; 95% CI, 0.083, 0.559; P = 0.002). Compared with patients in tertile 3, those in tertile 1 were at a much higher risk of endpoint (HR, 4.918; 95% CI, 1.076, 22.485; P = 0.040). Conclusions FT3 correlated with cardiac function and could serve as an independent predictor of all-cause mortality and cardiac transplantation in patients with HOCM. These results suggest that monitoring thyroid function in HOCM patients is necessary.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.2017-02386</identifier><language>eng</language><publisher>Washington: Copyright Oxford University Press</publisher><subject>Cardiomyopathy ; Correlation analysis ; Health risk assessment ; Heart transplantation ; Heart transplants ; Homeostasis ; Mortality ; Risk factors ; Thyroid gland ; Thyroid hormones ; Triiodothyronine ; Ventricle</subject><ispartof>The journal of clinical endocrinology and metabolism, 2018-03, Vol.103 (3), p.1198-1205</ispartof><rights>Copyright © Oxford University Press 2015</rights><rights>Copyright © 2018 Endocrine Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3796-eb5774e60a46b1b20bb9220b3623381b709553f29a3617934259a834df8ae22c3</citedby><cites>FETCH-LOGICAL-c3796-eb5774e60a46b1b20bb9220b3623381b709553f29a3617934259a834df8ae22c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2364277566?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,21388,21389,27924,27925,33530,33531,33744,33745,43659,43805,64385,64387,64389,72469,73123,73128,73129,73131</link.rule.ids></links><search><creatorcontrib>Zhang, Kuo</creatorcontrib><creatorcontrib>Meng, Xiangbin</creatorcontrib><creatorcontrib>Wang, Wenyao</creatorcontrib><creatorcontrib>Zheng, Jilin</creatorcontrib><creatorcontrib>An, Shimin</creatorcontrib><creatorcontrib>Wang, Siyuan</creatorcontrib><creatorcontrib>Qi, Yu</creatorcontrib><creatorcontrib>Gao, Chuanyu</creatorcontrib><creatorcontrib>Tang, Yi-Da</creatorcontrib><title>Prognostic Value of Free Triiodothyronine Level in Patients With Hypertrophic Obstructive Cardiomyopathy</title><title>The journal of clinical endocrinology and metabolism</title><description>Context Thyroid hormone acts as a fundamental regulator in cardiovascular homeostasis in pathophysiological conditions. Objective This study aims to determine whether thyroid hormone could be an independent predictor of adverse events in patients with hypertrophic obstructive cardiomyopathy (HOCM). Design, Patients, and Outcome Measures The original cohort consisted of 965 consecutive patients with HOCM who were admitted to Fuwai Hospital from October 2009 to December 2014, and 756 patients completed thyroid function evaluations. Patients were divided into three groups according to free triiodothyronine (FT3) levels: tertile 1 (<2.81 pg/mL, n = 247), tertile 2 (2.81 to 3.11 pg/mL, n = 250), tertile 3 (3.12 to 4.09 pg/mL, n = 259). Results In correlation analysis, FT3 showed significantly positive correlation with left ventricular ejection fraction (r = 0.109, P = 0.003). After a median follow-up of 44 months, a total of 45 (6.0%) endpoints (all-cause mortality or cardiac transplantation) occurred with rates of 13.4%, 3.6%, and 1.2% in tertiles 1, 2, and 3, respectively. Univariate Cox analysis established FT3 as a predictor of endpoint [hazard ratio (HR), 0.111; 95% confidence interval (CI), 0.065, 0.189; P < 0.001]. After adjustment for traditional risk factors, the prognostic value of FT3 level was still significant (HR, 0.216; 95% CI, 0.083, 0.559; P = 0.002). Compared with patients in tertile 3, those in tertile 1 were at a much higher risk of endpoint (HR, 4.918; 95% CI, 1.076, 22.485; P = 0.040). Conclusions FT3 correlated with cardiac function and could serve as an independent predictor of all-cause mortality and cardiac transplantation in patients with HOCM. These results suggest that monitoring thyroid function in HOCM patients is necessary.</description><subject>Cardiomyopathy</subject><subject>Correlation analysis</subject><subject>Health risk assessment</subject><subject>Heart transplantation</subject><subject>Heart transplants</subject><subject>Homeostasis</subject><subject>Mortality</subject><subject>Risk factors</subject><subject>Thyroid gland</subject><subject>Thyroid hormones</subject><subject>Triiodothyronine</subject><subject>Ventricle</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkTtPwzAURi0EEuUxsltiYUnxI7bjEVVAkSrBwGuznPSGuKRxsB1Q_j2BMrHcu5zv09W5CJ1RMqeMkstNNWeEqowwXsg9NKM6F5miWu2jGSGMZlqx10N0FOOGEJrngs9Q8xD8W-djchV-tu0A2Nf4JgDgx-CcX_vUjMF3rgO8gk9osevwg00OuhTxi0sNXo49hBR830wV92VMYaiS-wS8sGHt_Hb0vZ1KTtBBbdsIp3_7GD3dXD8ultnq_vZucbXKKq60zKAUSuUgic1lSUtGylKzaXLJOC9oqYgWgtdMWy6p0jxnQtuC5-u6sMBYxY_Rxa63D_5jgJjM1sUK2tZ24IdoqC604FJxMaHn_9CNH0I3XWcYlzlTSkg5UdmOqoKPMUBt-uC2NoyGEvPj3Wwq8-Pd_HqfeLrjv3ybIMT3dviCYBqwbWr-Z3a_4t9twYVt</recordid><startdate>201803</startdate><enddate>201803</enddate><creator>Zhang, Kuo</creator><creator>Meng, Xiangbin</creator><creator>Wang, Wenyao</creator><creator>Zheng, Jilin</creator><creator>An, Shimin</creator><creator>Wang, Siyuan</creator><creator>Qi, Yu</creator><creator>Gao, Chuanyu</creator><creator>Tang, Yi-Da</creator><general>Copyright Oxford University Press</general><general>Oxford University Press</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7T5</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>201803</creationdate><title>Prognostic Value of Free Triiodothyronine Level in Patients With Hypertrophic Obstructive Cardiomyopathy</title><author>Zhang, Kuo ; Meng, Xiangbin ; Wang, Wenyao ; Zheng, Jilin ; An, Shimin ; Wang, Siyuan ; Qi, Yu ; Gao, Chuanyu ; Tang, Yi-Da</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3796-eb5774e60a46b1b20bb9220b3623381b709553f29a3617934259a834df8ae22c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Cardiomyopathy</topic><topic>Correlation analysis</topic><topic>Health risk assessment</topic><topic>Heart transplantation</topic><topic>Heart transplants</topic><topic>Homeostasis</topic><topic>Mortality</topic><topic>Risk factors</topic><topic>Thyroid gland</topic><topic>Thyroid hormones</topic><topic>Triiodothyronine</topic><topic>Ventricle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Kuo</creatorcontrib><creatorcontrib>Meng, Xiangbin</creatorcontrib><creatorcontrib>Wang, Wenyao</creatorcontrib><creatorcontrib>Zheng, Jilin</creatorcontrib><creatorcontrib>An, Shimin</creatorcontrib><creatorcontrib>Wang, Siyuan</creatorcontrib><creatorcontrib>Qi, Yu</creatorcontrib><creatorcontrib>Gao, Chuanyu</creatorcontrib><creatorcontrib>Tang, Yi-Da</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Kuo</au><au>Meng, Xiangbin</au><au>Wang, Wenyao</au><au>Zheng, Jilin</au><au>An, Shimin</au><au>Wang, Siyuan</au><au>Qi, Yu</au><au>Gao, Chuanyu</au><au>Tang, Yi-Da</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic Value of Free Triiodothyronine Level in Patients With Hypertrophic Obstructive Cardiomyopathy</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><date>2018-03</date><risdate>2018</risdate><volume>103</volume><issue>3</issue><spage>1198</spage><epage>1205</epage><pages>1198-1205</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><abstract>Context Thyroid hormone acts as a fundamental regulator in cardiovascular homeostasis in pathophysiological conditions. Objective This study aims to determine whether thyroid hormone could be an independent predictor of adverse events in patients with hypertrophic obstructive cardiomyopathy (HOCM). Design, Patients, and Outcome Measures The original cohort consisted of 965 consecutive patients with HOCM who were admitted to Fuwai Hospital from October 2009 to December 2014, and 756 patients completed thyroid function evaluations. Patients were divided into three groups according to free triiodothyronine (FT3) levels: tertile 1 (<2.81 pg/mL, n = 247), tertile 2 (2.81 to 3.11 pg/mL, n = 250), tertile 3 (3.12 to 4.09 pg/mL, n = 259). Results In correlation analysis, FT3 showed significantly positive correlation with left ventricular ejection fraction (r = 0.109, P = 0.003). After a median follow-up of 44 months, a total of 45 (6.0%) endpoints (all-cause mortality or cardiac transplantation) occurred with rates of 13.4%, 3.6%, and 1.2% in tertiles 1, 2, and 3, respectively. Univariate Cox analysis established FT3 as a predictor of endpoint [hazard ratio (HR), 0.111; 95% confidence interval (CI), 0.065, 0.189; P < 0.001]. After adjustment for traditional risk factors, the prognostic value of FT3 level was still significant (HR, 0.216; 95% CI, 0.083, 0.559; P = 0.002). Compared with patients in tertile 3, those in tertile 1 were at a much higher risk of endpoint (HR, 4.918; 95% CI, 1.076, 22.485; P = 0.040). Conclusions FT3 correlated with cardiac function and could serve as an independent predictor of all-cause mortality and cardiac transplantation in patients with HOCM. These results suggest that monitoring thyroid function in HOCM patients is necessary.</abstract><cop>Washington</cop><pub>Copyright Oxford University Press</pub><doi>10.1210/jc.2017-02386</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Cardiomyopathy Correlation analysis Health risk assessment Heart transplantation Heart transplants Homeostasis Mortality Risk factors Thyroid gland Thyroid hormones Triiodothyronine Ventricle |
| title | Prognostic Value of Free Triiodothyronine Level in Patients With Hypertrophic Obstructive Cardiomyopathy |
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